Genomics

Dataset Information

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RNA-seq in NT, CAP-D3, and CAP-H2 expressing cells treated with DMSO or menadione


ABSTRACT: RNA-seq in NT, CAP-D3, and CAP-H2 expressing cells treated with DMSO or menadione

PROVIDER: PRJNA580225 | ENA |

REPOSITORIES: ENA

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Publications

Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses.

Deutschman Emily E   Ward Jacqueline R JR   Kumar Avinash A   Ray Greeshma G   Welch Nicole N   Lemieux Madeleine E ME   Dasarathy Srinivisan S   Longworth Michelle S MS  

Journal of cell science 20191120 22


The maintenance of mitochondrial respiratory function and homeostasis is essential to human health. Here, we identify condensin II subunits as novel regulators of mitochondrial respiration and mitochondrial stress responses. Condensin II is present in the nucleus and cytoplasm. While the effects of condensin II depletion on nuclear genome organization are well studied, the effects on essential cytoplasmic and metabolic processes are not as well understood. Excitingly, we observe that condensin I  ...[more]

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