Genomics

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Neuronal expression of Alzheimer's disease-associated FAD mouse genotype at 3/6/12 months


ABSTRACT: Neuronal expression of Alzheimer's disease-associated FAD mouse genotype at 3/6/12 months

PROVIDER: PRJNA589094 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR10435311_1.fastq.gz Fastqsanger.gz
SRR10435311_2.fastq.gz Fastqsanger.gz
SRR10435312_1.fastq.gz Fastqsanger.gz
SRR10435312_2.fastq.gz Fastqsanger.gz
SRR10435313_1.fastq.gz Fastqsanger.gz
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Publications


Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two independent cohorts, showing partial RNA dependency. Comparisons of brain tissue and cerebrospinal fluid proteomes reveal biomarker candidates. Combining with 5xFAD mouse analysis,  ...[more]

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