Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Altered expression and Downstream targets of uc.323

ABSTRACT: Altered expression and Downstream targets of uc.323

PROVIDER: PRJNA592899 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Downstream targets of uc.323-mediated cardiomyocyte hypertrophy

Project description:To further characterize the downstream targets of uc.323, we performed global microarray analysis after knockdown of uc.323 in cardiomyocytes to gain broad insight into uc.323-mediated transcriptome changes.

2019-11-30 | GSE141166 | GEO

Downstream targets of uc.323-mediated cardiomyocyte hypertrophy

Project description:Downstream targets of uc.323-mediated cardiomyocyte hypertrophy

| PRJNA592523 | ENA

Altered expression and Downstream targets of uc.323

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-03 | GSE141234 | GEO

Altered expression of uc.323 during aortic banding-induced cardiac hypertrophy in mice

Project description:Altered expression of uc.323 during aortic banding-induced cardiac hypertrophy in mice

| PRJNA592524 | ENA

Pouch transcriptional differences between UC and FAP indicate altered immune response.

Project description:A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and selected patients with ulcerative colitis (UC). However, this surgical treatment often associates with a long-term complication, pouchitis, which occurs mostly in UC patients. To better define the molecular background of pouchitis, the microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients operated for UC and FAP, respectively. A number of 4771 genes was significantly differentiating uninflamed from inflamed mucosal samples, and their functional features were represented mostly by alerted metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed probe sets between UC and FAP samples, irrespectively of mucosal inflammation status, revealed multiple pathways and terms which were linked to changes in immune response. Noteworthy, the comparison of uninflamed UC and FAP samples distinguished a set of 26 altered mRNAs including inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most discrete changes in gene expression profiles differentiating uninflamed UC and FAP mucosal samples were attributed to a Gene Ontology category innate immune response. Our study confirmed alterations of the immune responses as dominant in UC pouchitis which were earlier found in the studies using analyses of singular molecular elements. This observation may be important when managing IPAA patients. Each sample represents three biopsies taken from single patient, from the same areas of the lower part of the pouch mucosa (above the rectal cuff) during endoscopic examination. 28 patients underwent surgery for UC and 8 patients for FAP.

2014-05-01 | E-GEOD-50788 | biostudies-arrayexpress

Identification of miR-154 downstream targets

Project description:Identification of miR-154 downstream targets

| PRJNA593019 | ENA

Pouch transcriptional differences between UC and FAP indicate altered immune response.

2014-05-01 | GSE50788 | GEO

miRNA changes after overexpression of uc.372 in HepG2 cells

Project description:To identify putative miRNA targets for uc.372, we overexpressed uc.372 in HepG2 cells and carried out a microarray analysis. A total of 66 miRNAs present in the array demonstrated 1.5-fold upregulation or downregulation of expression upon uc.372 transfection.

2017-11-01 | GSE106366 | GEO

Downstream targets of ATR in CIN612 HPV-positive cells

Project description:Downstream targets of ATR in CIN612 HPV-positive cells

| PRJNA597129 | ENA

Identification of STAT3 downstream targets involved in chemoradiotherapy resistance

Project description:Identification of STAT3 downstream targets involved in chemoradiotherapy resistance

| PRJNA579909 | ENA