Project description:Hepatitis C virus intrinsic molecular determinants may contribute to the development of cholestatic hepatitis after transplantation

| PRJNA493793 | ENA

Hepacivirus C

Project description:Quasispecies dynamics in hepatitis C liver transplant recipients receiving grafts from hepatitis C virus infected donors

| PRJNA277329 | ENA

Hepacivirus C

Project description:Resistance of high fitness hepatitis C virus to lethal mutagenesis

| PRJNA720288 | ENA

Sandip2013 - Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin.

Project description:Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin. Banerjee S1, Keval R, Gakkhar S. Author information 1 Department of Mathematics, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttaranchal, India. Electronic address: sandofma@iitr.ernet.in. Abstract A mathematical modeling of hepatitis C virus (HCV) dynamics and antiviral therapy has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected cells, infectious virions and non-infectious virions. The model takes into consideration the addition of ribavirin to interferon therapy and explains the dynamics regarding a biphasic and triphasic decline of viral load in the model. A critical drug efficacy parameter has been defined and it is shown that for an efficacy above this critical value, HCV is eradicated whereas for efficacy lower this critical value, a new steady state for infectious virions is reached, which is lower than the previous steady state value. Copyright © 2013 Elsevier Inc. All rights reserved. KEYWORDS: Hepatitis C virus (HCV); Infected cells; Infectious virions; Interferon; Noninfectious virions; Ribavirin; Target cells

2019-12-13 | BIOMD0000000892 | BioModels

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