Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Targeting transcriptional control activity of long mononucleotide A-T repeats in lung cancer stem cells

ABSTRACT: Targeting transcriptional control activity of long mononucleotide A-T repeats in lung cancer stem cells

PROVIDER: PRJNA597762 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The cis-regulatory function of long mononucleotide A-T repeats in maintaining high transcription activity in cancer

Project description:The cis-regulatory function of long mononucleotide A-T repeats in maintaining high transcription activity in cancer

| PRJNA477540 | ENA

Targeting transcriptional control activity of long mononucleotide A-T repeats in lung cancer stem cells

Project description:To explore gene expression profiles in spheroid lung cancer cell line after transfection PNA-A (15) that shown potential reduce cell proliferation and cell growth.

2019-12-27 | GSE142616 | GEO

Targeting multiple genes containing long mononucleotide A-T repeats in lung cancer stem cells.

Project description: Not available

| S-EPMC8166091 | biostudies-literature

CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats

Project description:CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats

| PRJNA531700 | ENA

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice

Project description:NAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ biosynthesis and ameliorate various pathologies in mouse disease models. In this study, we conducted a 12 month-long NMN administration to regular chow-fed wild-type C57BL/6N mice during their normal aging. Orally administered NMN was quickly utilized to synthesize NAD+ in tissues. Remarkably, NMN effectively mitigates age-associated physiological decline in mice. Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies. Consistent with these phenotypes, NMN prevented age-associated gene expression changes in key metabolic organs and enhanced mitochondrial oxidative metabolism and mitonuclear protein imbalance in skeletal muscle. These effects of NMN highlight the preventive and therapeutic potential of NAD+ intermediates as effective anti-aging interventions in humans.

2016-12-01 | GSE85718 | GEO

The cis-regulatory function of long mononucleotide A-T repeats in maintaining high transcription activity in cancer

Project description:To explore gene expression profiles in A549 lung cancer cell line after transfection CPP-AGO1-polyUs that shown potential reduce cell proliferation and cell growth.

2018-06-23 | GSE116168 | GEO

Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis and Cell Growth

Project description:In the present study, we developed a chemical method to produce dihydro nicotinamide mononucleotide (NMNH), which is the reduced-form of nicotinamide mononucleotide (NMN). We demonstrated that NMNH was a better nicotinamide adenine dinucleotide (NAD+) enhancer compared to NMN both in vitro and in vivo mediated by mononucleotide adenylyltransferase (NMNAT). Additionally, NMNH increased the reduced NAD (NADH) levels in cells and in mouse liver. Metabolomic analysis revealed that NMNH inhibited glycolysis and TCA cycle. In vitro experiments demonstrated that NMNH induced cell cycle arrest and suppressed cell growth. Nevertheless, NMNH treatment did not cause observable difference in mice. Taken together, our work demonstrates that NMNH is a potent NAD+ enhancer, and suppresses glycometabolism and cell growth.

2022-02-25 | PXD022547 | Pride

Nicotinamide Mononucleotide administration prevents doxorubicin-induced cardiotoxicity and loss in physical activity in mice.

Project description:In this study we investigated whether nicotinamide mononucleotide (NMN) could protect against Doxorubicin-induced cardiotoxicity and physical dysfunction in vivo. To assess the short- and long-term toxicity, two Doxo regimens were tested, acute and chronic. In the acute study, C57BL6/J (B6) mice were injected intraperitoneally (i.p.) once with Doxo (20 mg/kg) and NMN (180 mg/kg/day, i.p.) was administered daily for five days before and after the Doxo injection. In the chronic study, B6 mice received a cumulative dose of 20 mg/kg Doxo administered in fractionated doses for five days. NMN (500 mg/kg/day) was supplied in the mice’s drinking water beginning five days before the first injection of Doxo and continuing for 60 days after.

2023-01-11 | GSE221003 | GEO

Mononucleotide repeat instability in blood

Project description:Analysis of mononucleotide repeat instability in blood using amplicon sequencing

| PRJEB39600 | ENA

Mononucleotide repeats are asymmetrically distributed in fungal genes.

Project description: Not available

| S-EPMC2621210 | biostudies-literature