Project description:Gastroentero-pancreatic neuroendocrine neoplasm(GEP-NEN) is consisted of neuroendocrine tumor and neuroendocrine carcinoma, which is a lethal, but under-investigated disease owing to its rarity. We established an organoid library of GEP-NEN and added their comprehensive molecular characterization.
Project description:In the present study, we established organoids using cancer and non-cancer tissues obtained from patients with biliary tract carcinomas and investigated compehensive gene expression profiles.
Project description:We report the generation and characterization of tumor organoids and PDOX derived from needle biopsies of metastatic lesions from neuroendocrine prostate cancer patients.
Project description:In the present study, we established organoids using cancer and non-cancer tissues obtained from patients with biliary tract carcinomas and investigated compehensive microRNA expression profiles.
Project description:In the present study, we established organoids using cancer and non-cancer tissues obtained from patients with biliary tract carcinomas and investigated compehensive microRNA expression profiles.
Project description:Accumulating evidence indicates that patient- derived organoids (PDOs) can predict drug responses in the clinic. Metastasis is the main cause of death in colorectal cancer patients, and the treatment of patients with liver metastasis remains poor. Tumor heterogeneity is the cause of treatment failure. In this study, we aim the investigate the consistency of drug sensitivity for the matched primary and metastatic tumor in patients with liver metastasis.