Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell transcriptomics of index-sorted human bone marrow CD34+ progenitors

ABSTRACT: Single cell transcriptomics of index-sorted human bone marrow CD34+ progenitors

PROVIDER: PRJNA598850 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Single cell transcriptomics of index-sorted human bone marrow CD34+ progenitors

Project description:The transcriptomes of single cells from human bone marrow were investigated at single cell level, with the aim to reconstruct the development of human dendritic cell lineages.

2020-08-01 | GSE142999 | GEO

RNA-Seq of CD34+ Bone Marrow Progenitors from Healthy Donors

Project description:To evaluate the transcriptome and splicing repertoire of bulk CD34+ sorted bone marrow progenitors we performed RNA-Seq. These data highlight an AML prognostic splicing signature that is present in healthy donors at equivalent frequencies to that found in AML bone marrow.

2019-08-22 | GSE118944 | GEO

RNA-Seq of CD34+ Bone Marrow Progenitors from Healthy Donors

Project description:RNA-Seq of CD34+ Bone Marrow Progenitors from Healthy Donors

| PRJNA487456 | ENA

Transcription profiling of mouse HSC(CD34-KSL cells) and progenitors (CD34+KSL cells)

Project description:Gene expression profile between HSC(CD34-KSL cells) and Progenitors(CD34+KSL cells) were compared.

2010-06-18 | E-MEXP-2223 | biostudies-arrayexpress

Single cell transcriptomics of index-sorted human bone marrow mature dendritic cells and precursors

Project description:Single cell transcriptomics of index-sorted human bone marrow mature dendritic cells and precursors

| PRJNA598852 | ENA

Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow

Project description:In mice, two restricted DC progenitors, macrophage-dendritic progenitor (MDP) and common dendritic cell progenitor (CDP) demonstrate increasing commitment of DC lineage as they sequentially lose granulocyte and monocyte potential respectively. Identifying these progenitors has enabled understanding of the role of DCs and monocytes in immunity and tolerance in mice. In humans, however, restricted monocyte and DC progenitors remain unknown. Progress in studying human DC development has been hampered by lack of an in vitro culture system that recapitulates in vivo DC hematopoiesis. Here we report a culture system that supports development of CD34+ hematopoietic stem cell progenitors into the three major human DC subsets, monocytes, granulocytes, NK and B cells. Using this culture system we defined the pathway for human DC development, and revealed the sequential origin of human DCs from increasingly restricted progenitors: a granulocyte-monocyte-DC progenitor (hGMDP) that develops into a monocyte-DC progenitor (hMDP) that develops into monocytes and a common DC progenitor (hCDP) that is restricted to produce the three major DC subsets. The phenotype of the DC progenitors partially overlaps with granulocyte monocyte progenitors (GMPs). These progenitors reside in human cord blood and bone marrow but not in the blood or lymphoid tissues in the steady state. We performed whole transcriptome expression analysis on monocytes and subsets of dendritic cells i.e. CD1c+ DCs, CD141+ DCs and CD303+ pDCs isolated from blood or differentiated in culture from cord blood CD34+ cells in presence of MS5 stromal cells and Flt3l, GM-CSF and SCF cytokines.

2015-01-22 | E-GEOD-65128 | biostudies-arrayexpress

Single cell transcriptomics of index-sorted human bone marrow mature dendritic cells and precursors

Project description:The transcriptomes of single cells from human bone marrow were investigated at single cell level, with the aim to reconstruct the development of human dendritic cell (DC) lineages.

2020-08-01 | GSE143002 | GEO

Uncovering novel human CD34+ and CD34dim/- neutrophil progenitors

Project description:Uncovering novel human CD34+ and CD34dim/- neutrophil progenitors

| PRJNA691558 | ENA

Differentiation timecourse of MK and EB from CD34+ progenitors

Project description:In vitro differentiation of CD34+ haematopoietic progenitors into megakaryocytes and erythroblasts in paired samples

2011-07-07 | E-MTAB-712 | biostudies-arrayexpress

Gene expression profiles of basophil progenitors, CD34- pre-basophils and mature basophils

Project description:In this study, we explored gene expression profiles of CD34-CLEC12Ahi pre-basophils isolated from the bone marrow as well as CD34-CLEC12Alo mature basophils from the bone marrow and CD34+ basophil progenitors. We revealed that the gene expression of mature basophils isolated from the bone marrow and spleen resembled each other whereas pre-basophils and mature basophils showed distinct gene expression profiles.

2023-03-21 | GSE206591 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data