Project description:To reveal the mechanisms of FGF13A in regulation of neural progenitor development, we carried out RNA-seq gene expression profiling analysis in primarily cultured neurospheres from neonatal FGF13Aoe mice. 2 biological independent sample from FGF13oe (hGAFPCre+;ROSA26FGF13A LSL/+) mice mice were compared with 2 independentlitermate control(hGAFPCre+, ROSA26FGF13A +/+) samples.
Project description:To reveal the mechanisms of FGF13 in regulation of neural progenitor development, we carried out RNA-seq gene expression profiling analysis in primarily cultured hippocampal neurospheres from FGF13cko mice. 3 biological independent samples from FGF13cko (hGAFPCre+;Fgf13 flox/y) mice were compared with 3 independent litermate control (hGAFPCre+;Fgf13 +/y) samples.
Project description:To identify ARID1B associated genes in development of neural progenitor , we carried out RNA-seq gene expression profiling analysis in primarily cultured neurospheres from ARID1B haploinsufficient and control mice. 3 biological independent sample from ARID1B hi (hGAFPCre+;ARID1B flox/+) mice were compared with 2 independent litermate control (hGAFPCre+; ARID1B +/+) samples.
Project description:To identify the changes of chromatin structure in neural progenitors upon Fgf13 depletion, we compared the chromatin accessibility of primarily cultured hippocampal neurosphere from neonatal FGF13cko (hGAFPCre+;Fgf13 flox/y) mice and litermate control (hGAFPCre+;Fgf13 +/y) mice by ATAC-seq analysis.