Project description:Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover important tumor biology and/or yield promising therapeutic insights. Here we investigated the role of circular RNAs (circRNA) in metastasis, using melanoma as a model aggressive tumor. We identified silencing of Cerebellar Degeneration Related 1 (CDR1as), a regulator of the microRNA miR-7, as a hallmark of melanoma progression. We find that CDR1as depletion results from epigenetic silencing of its originating lincRNA, and promotes invasion in vitro and metastasis in vivo, through a miR-7-independent, IGF2BP3-mediated mechanism. Moreover, CDR1as levels identify cellular states associated with distinct therapeutic responses. Our study reveals functional, prognostic and predictive roles for CDR1as and expose circRNAs as key players in metastasis.

2020-01-13 | GSE138710 | GEO

Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RNA-Seq]

2020-01-13 | GSE138412 | GEO

miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner

Project description:To investigate interactions of Cdr1as and miR-7 in mouse neuron, we cultured primary mouse cell in which each target gene has been knocked out from C57BL/6N mouse and overexpression of pri-miR-7a

2024-04-26 | GSE224184 | GEO

RNA-seq analysis regarding adrenal gland contribution in mouse steroid synthesis

Project description:RNA-seq analysis regarding adrenal gland contribution in mouse steroid synthesis

| PRJNA483136 | ENA

Comprehensive transcriptome analysis regarding aging using normal human derived fibroblasts (NHDF)

Project description:We determined the gene expression changes by the cDNA status using NHDF cells at early passage and at later passage

2018-11-30 | GSE107483 | GEO

Comprehensive analysis of Transcriptome Profiles in Hepatocellular Carcinoma patients

Project description:Comprehensive analysis of Transcriptome Profiles in Hepatocellular Carcinoma patients

| PRJNA414787 | ENA