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Next generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS

ABSTRACT: Next generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS

PROVIDER: PRJNA601333 | ENA |

REPOSITORIES: ENA

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Next generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS

Project description:To investigate the effect of MGL ligation in monocyte-derived dendritic cell biology, we generated control dendrimers and two different glycodendrimers exposing the MGL ligands αGalNAc or GalNAcβ1-4Gal. αGalNAc and GalNAcβ1-4Gal glycodendrimers were validated in the corresponding manuscript. Monocyte-derirved dendritic cells were generated by culturing monocytes for 4 days with IL-4 and GM-CSF. To study the effect of MGL-ligation at the transcriptional level, next generation sequencing was performed on monocyte-derived dendritic cells from three independent donors, stimulated for 4 h with control, αGalNAc or GalNAcβ1-4Gal glycodendrimers in the absence or presence of LPS.

2020-02-18 | GSE143699 | GEO

Next-generation sequencing of human monocyte-derived dendritic cells stimulated with sialic acid glycodendrimers in the absence or presence of LPS

Project description:To investigate whether a2-3 sialic acid dendrimers that bind to Siglec-9 would alter signalling and reprogramming of human monocyte-derived dendritic cells with and without LPS.

2021-06-23 | GSE168887 | GEO

Transcriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept

Project description:We measured TNFÎ± activity on the transcriptional level by identifying TNFÎ±-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFÎ± does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a wide range of immunologically active factors, including TNFÎ±. In order to identify gene expression attributable to LPS-induced TNFÎ±, we compared the transcriptome of MDM 24 hours after stimulation with 100 ng/ml ultra-pure LPS in the presence and absence of the soluble TNF receptor fusion protein Etanercept (10 Âµg/ml).

2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress

Transcription profiling by array of human monocyte-derived dendritic cells induced by TLR agonists in the presence or absence of PP2

Project description:Analysis of monocyte-derived dendritic cells (MoDC) gene expression signature induced by TLR agonists the in presence or in the absence of PP2.

2010-06-18 | E-TABM-1018 | biostudies-arrayexpress

Next-generation sequencing of human monocyte-derived dendritic cells stimulated with sialic acid glycodendrimers in the absence or presence of LPS

Project description:Next-generation sequencing of human monocyte-derived dendritic cells stimulated with sialic acid glycodendrimers in the absence or presence of LPS

| PRJNA714419 | ENA

Transcription profiling of human resting and zymosan A-stimulated monocyte-derived macrophages in the absence or presence of PMN-Ectosomes

Project description:In order to define the inhibitory activity of PMN-Ectosomes, we investigated the early gene expression profiles of resting and zymosan A-stimulated human monocyte-derived macrophages in the absence or presence of PMN-Ectosomes. Experiment Overall Design: We cultured monocytes isolated from fresh buffy coats of 4 healthy donors (2 males and 2 females between the ages of 20 to 45) for 7 days at 37Â°C. At day 7, macrophages were cultured for another 3 hours alone, in presence of PMN-Ectosomes, with zymosan A, and with zymosan A and PMN-Ectosomes.

2009-01-25 | E-GEOD-14419 | biostudies-arrayexpress

Transcription profiling time series of mouse bone marrow macrophages treated with macrophage colony stimulating factor or granulocyte colony stimulating factor

Project description:BM monocytes were treated with 20ug/ml of M-CSF (macrophage colony stimulating factor) or GM-CSF (granulocyte monocyte colony stimulating factor) for 0, 6, 12 hours before harvesting RNA for analysis

2008-11-01 | E-MEXP-1803 | biostudies-arrayexpress

Human monocyte-derived macrophages polarized by GM-CSF (M1) or M-CSF (M2) in the presence or absence of 50 nanomolar Methotrexate

Project description:Identification of genes differentially expressed between human monocyte-macrophages generated in the presence of either GM-CSF (termed M1) or M-CSF (termed M2) and in the presence (+MTX) or absence (-) of Methotrexate

2017-05-08 | GSE71253 | GEO

Human monocyte-derived macrophages polarized by GM-CSF (M1) or M-CSF (M2) in the presence or absence of 5 micromolar methotrexate

2020-12-31 | GSE64531 | GEO

Analysis of gene expression of LPS-stimulated monocyte from CAD patients

Project description:Dissection the impact of CVD risk factors on monocyte phenotype at the gene expression level , and in particular on their response to trauma and infection response.

2023-06-11 | GSE234398 | GEO

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