Project description:We aim to the investigate the role of ZNF213 in breast cancer progression. MCF-7 cells were used as the model , ZNF213 was silenced by siRNA.

2021-01-19 | GSE143948 | GEO

Genome wide expression change by RNF181 knockdown in MCF-7 cells

Project description:We aim to the investigate the role of RNF181 in breast cancer progression. MCF-7 cells were used as the model , RNF181 was silenced by siRNA.

2021-01-19 | GSE143947 | GEO

Genome wide expression change by MCF-7 cells treated with MST1/2 inhibitor

Project description:Genome wide expression change by MCF-7 cells treated with MST1/2 inhibitor

| PRJNA693878 | ENA

Genome-wide DNA methylation change due to H19 knockdown and TET3 knockdown in UtLM

Project description:We used Methyl-MiniSeq platform from Zymo Research company to identify genome-wide methylation changes affected by H19 knockdown and TET3 knockdown in human UtLM. Following H19 and TET3 knockdown, we observed extensive genome-wide methylation pattern changes relative to siCon cells, with some genes showing increased methylation, others showing decreased methylation, and a third group with no significant change.

2021-07-16 | GSE117190 | GEO

Genome-wide expression change by SHARPIN knockdown in MCF-7 cells

Project description:We aim to investigate the role of SHARPIN in breast cancer progression. MCF-7 cells were used as the model and SHARPIN was silenced by siRNA.SHARPIN (SHANK-Associated RH Domain Interactor) is also named as SIPL1 and HSIPL1. The gene is located in Chr 8. SHARPIN protein is shown to regulate cell adhesion and migration. Besides, SHARPIN is proved to the component of the LUBAC complex and is necessary for NKFB function, while SHARPIN KO mice will lead to chronic dermatitis and immune deficiency in B cells.

2017-01-01 | GSE77261 | GEO

Genome-wide DNA methylation change due to lncRNA H19 knockdown in myotubes

Project description:We used Methyl-MiniSeq platform from Zymo Research company to identify genome-wide methylation changes affected by lncRNA H19 knockdown in myotubes. Following H19 knockdown, we observed extensive genome-wide mthylation pattern changes relative to siCon cells, with some genes showing incresed methylation, others showing decreased methylation, and a third group with no significant change.

2015-11-09 | GSE73013 | GEO

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