Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional profiling of WT-ProB, WT-PreB and ProB cells from Rag1ko/ko, IghTer5H/Ter5H, IghTer5 /wt;Rag1ko/ko , IghTer5H∆TM/ Ter5H∆TM and IghTer5H∆TM/ Ter5H∆TM ;Rag1ko/ko mice

ABSTRACT: Transcriptional profiling of WT-ProB, WT-PreB and ProB cells from Rag1ko/ko, IghTer5H/Ter5H, IghTer5 /wt;Rag1ko/ko , IghTer5H∆TM/ Ter5H∆TM and IghTer5H∆TM/ Ter5H∆TM ;Rag1ko/ko mice

PROVIDER: PRJNA603287 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptional profiling of WT-ProB, WT-PreB and ProB cells from Rag1ko/ko, IghTer5H/Ter5H, IghTer5 /wt;Rag1ko/ko , IghTer5H∆TM/ Ter5H∆TM and IghTer5H∆TM/ Ter5H∆TM ;Rag1ko/ko mice

Project description:We studied the role of the stable Igh mRNA in Igh chain check point. Here we generated RNA-seq data from sorted ProB (CD19+B220+c-Kit+CD25-) and PreB (CD19+B220+c-Kit-CD25+) populations from Bone marrow of mice.

2020-12-29 | GSE144275 | GEO

Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia revealing secondary genomic alterations in histone modification genes

Project description:We used microarrays to investigate gene expression changes in ETV6/RUNX1 proB and preB cells Bone marrow proB and preB cells of four ETV6/RUNX1 mice compared with bone marrow proB and preB cells of three WT mice and three Pax5+/- mice.

2015-07-03 | E-GEOD-70492 | biostudies-arrayexpress

RNA- and ATAC-seq data of Wt, Ebf1-KO and Pax5-KO FL-ProB-cells.

Project description:EBF1 and PAX5 are crucial factors for B-cell development. Knock down of either factor leads to an arrest in differentiation. RNA-seq data of WT, Ebf1-/- and Pax5-/- FL-ProB cells allowed for identification of activated and repressed target genes. ATAC-seq data of corresponding cell populations could connect gene activity and chromatin accessibility. This finding provided an explanation to the lineage instability observed in early B-cell progenitors. Taken together, the reported data provide an increased insight into mechanisms governing regulation of stage- and lineage specific transcription in early B-lymphocyte development.

2018-06-08 | GSE92434 | GEO

The role of Erg in B cell development (ATAC-Seq)

Project description:ATAC-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow, and pre-proB, proB and preB populations from from Rag1CreT/+;ErgΔ/Δ;IgHVH10tar bone marrow.

2020-04-14 | GSE132852 | GEO

C/EBPb cooperates with BLNK mutation in preB leukemogenesis (BLNK2)

Project description:BLNK (BASH/SLP-65) encodes an adaptor protein within the B-cell receptor signaling. Loss-of-function mutations of BLNK are observed in human preB-ALL, and a subset of Blnk knock-out mice develop preB-ALL. To understand the molecular mechanism of preB-ALL development associated with the Blnk mutation, retroviral tagging was applied on Blnk KO mice using Moloney murine leukemia virus (MoMLV). The Blnk mutation significantly accelerated the disease onset of MoMLV-induced leukemia and increased the incidence of preB-ALL. Cebpb was identified as the most frequent common retroviral integration site, suggesting that Cebpb upregulation cooperates with Blnk mutation. Transgenic expression of the LAP (liver-enriched activator protein) isoform of C/EBP-beta significantly accelerated preB-ALL development of Blnk ko mice. We used microarrays to detail the global program of gene expression in mouse preB-ALL

2021-10-27 | GSE110738 | GEO

C/EBPb cooperates with BLNK mutation in preB leukemogenesis (BLNK1)

2021-10-27 | GSE110737 | GEO

The role of Erg in B cell development (RNA-Seq)

Project description:RNA-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow

2020-04-14 | GSE132854 | GEO

B cells sorted from VHL floxed MB1- Cre

Project description:ProB-PreB, immature and mature B cells were sorted from the bone marrow of mice and the RNA subsequently sequenced. The mice were all Mb1-Cre +/- and either Vhl flox/flox or VHL flox/WT

2020-07-13 | GSE129513 | GEO