Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation

ABSTRACT: CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation

PROVIDER: PRJNA605240 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation [GE]

2020-03-16 | GSE144896 | GEO

CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation [ME]

Project description:Intraclonal subpopulations of circulating chronic lymphocytic leukemia (CLL) cells with different proliferative histories and reciprocal surface expression of CXCR4 and CD5 have been observed in the peripheral blood of CLL patients and named proliferative (PF), intermediate (IF) and resting (RF) cellular fractions. Here we found that these intraclonal circulating fractions share persistent DNA methylation signatures largely associated with the mutation status of the immunoglobulin heavy chain locus (IGHV) and their origins from distinct stages of differentiation of antigen-experienced B-cells. Increased leukemic birth rate (BR), however, showed a very limited impact on DNA methylation of circulating CLL fractions independent of IGHV mutation status. Additionally, DNA methylation heterogeneity increased as leukemic cells advanced from PF to RF in the peripheral blood. This frequently co-occurred with heterochromatin hypomethylation and hypermethylation of Polycomb-repressed regions in the PF, suggesting accumulation of longevity-associated epigenetic features in recently born cells.

2020-03-16 | GSE144894 | GEO

CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation [ME]

Project description:CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation [ME]

| PRJNA605239 | ENA

CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation [GE]

Project description:CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation [GE]

| PRJNA605242 | ENA

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation.

Project description: Not available

| S-EPMC7065474 | biostudies-literature

CLL intraclonal fractions exhibit established and recently-acquired patterns of DNA methylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-16 | GSE144901 | GEO

Reverse Osmosis Membranes Fractions

Project description:Reverse Osmosis Membranes Fractions Raw sequence reads

| PRJNA629347 | ENA

scRNAseq of established brain metastasis

Project description:scRNAseq of established brain metastasis

| PRJNA781204 | ENA

Transcript sequencing of mononuclear fractions from dissociated murine skeletal muscle

Project description:The important role of mesenchymal progenitors is quickly emerging in various biological processes. Thus far an appropriate marker has been lacking. Here the fractionation of dissociated skeletal muscle and subsequent enrichment of MPs by an established method was employed. Endothelial and blood derived cells comprised the lineage positive fraction and the remaining cell suspension was fractionated using the surface marker Sca1(Ly6a) to enrich for MPs. RNA sequencing was performed on all fractions and subsequent transcriptomic data was interrogated for MP specific transcription factors. Hic1 was found to be highly enriched in the MP fraction.

2019-12-05 | GSE110013 | GEO

recently deglaciated unvegetated glacier forefields

Project description:Colonization of recently deglaciated unvegetaded glacier forefields in the Swiss Alps

| PRJEB9484 | ENA