Project description:Nonalcoholic steatohepatitis (NASH) is an aggressive liver disease threatening public health, however its natural history is poorly understood. Unlike ob/ob mice, Lep∆I14/∆I14 rats develop unique NASH phenotype with an inflection point of inflammation at postnatal week 16. Using Lep∆I14/∆I14 rats, we studied the natural history of NASH progression by performing an integrated analysis of hepatic transcriptome from postnatal week 4 to 48. Leptin deficiency leads to the precipitously increasing expression of genes encoding rate-limiting enzymes in lipid metabolism. However, hepatic inflammation related genes, pathways and immune-cell infiltration are restricted after week 16, implying an essential role of LEPTIN in regulating hepatic inflammation. Lep∆I14/∆I14 rats share more genes with NASH patients than known mouse models, therefore will provide a better genetic platform for studying NASH than mice.

2019-12-31 | GSE124002 | GEO

The Natural History of Mucolipidosis Type IV - LDN 6704

Project description:The Natural History of Mucolipidosis Type IV - LDN 6704

| PRJNA378815 | ENA

Genetics, Cellular and Natural History of X-Linked Dystonia Parkinsonism

Project description:Genetics, Cellular and Natural History of X-Linked Dystonia Parkinsonism

| PRJNA430957 | ENA

Genetics, Cellular and Natural History of X-Linked Dystonia Parkinsonism

Project description:Genetics, Cellular and Natural History of X-Linked Dystonia Parkinsonism

| PRJNA430958 | ENA

Apparent Mineralocorticoid Excess Syndrome Natural History Clinical Protocol - RGSDC 5601

Project description:Apparent Mineralocorticoid Excess Syndrome Natural History Clinical Protocol - RGSDC 5601