Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ATAC-seq]

ABSTRACT: DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ATAC-seq]

PROVIDER: PRJNA607520 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DNA G-quadruplexes modulate highly transcribed genes in human chromatin

Project description:DNA G-quadruplexes modulate highly transcribed genes in human chromatin

| PRJNA607527 | ENA

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

Project description:DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

| PRJNA607517 | ENA

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [RNA-seq]

Project description:DNA G-quadruplexes modulate highly transcribed genes in human chromatin [RNA-seq]

| PRJNA607526 | ENA

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ATAC-seq]

Project description:G4s are nucleic acids secondary structures that form in the presence of four or more runs of gunanine. In vitro results suggested that G4s are involved in the regulation of both transcription and replication processes. In vitro results suggested that G4s are involved in the regulation of both transcription 6–10 and replication 11–13 processes allowed to demonstrate the actual folding of G4s in live cells, but also inserted them in a more biologically relevant context. . In the present work we mapped G4s in the chromatin of a WD-LPS cell line (93T449), we integrated the information of G4 folding with their chromatin context, the transcriptional level of the associated genes and compared the results with data obtained in a cell line of different origin (HaCaT).

2021-04-26 | GSE145532 | GEO

DNA G-quadruplexes modulate highly transcribed genes in human chromatin

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-26 | GSE145543 | GEO

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

2021-04-26 | GSE145535 | GEO

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [RNA-seq]

2021-04-26 | GSE145537 | GEO

Sumoylation regulates general transcription factors at promoters of highly transcribed genes

Project description:Sumoylation regulates general transcription factors at promoters of highly transcribed genes

| PRJNA704633 | ENA

Condensin mediates the chromosomal clustering of highly transcribed genes in bacteria

Project description:Purpose: Study MukB, RNAP, TopA, and ParC binding profiles on E.coli chromosome. Methods: We constructed affinity tagged MukB, ParC, and TopA strains, and immunoprecipitated using anti-FLAG antibodies as well as an RNAP primary antibody. Results: MukB, RNAP, TopA, and ParC were all bound to rDNAs on the coding sequences, as well as the coding regions of 244 highly transcribed genes, including tRNAs, genes coding for ribosomal proteins, housekeeping genes (for example, atpA and rpoB), as well as OriC. Conclusions: We found that the bacterial condensin, MukB, is recruited to actively transcribed genes such as rDNA through transcription induced supercoiling.

2015-05-29 | GSE69250 | GEO

Native G-quadruplexes Stabilization Impairs Transcription Initiation

Project description:G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines. They are distributed genome-widely and participate in multiple biological processes including gene transcription, and quadruplex-targeted ligands serve as potential therapeutic agents for DNA-targeted therapies. However, the roles of G-quadruplexes in transcriptional regulation remains elusive. Here, we establish a sensitive G4-CUT&Tag method for genome-wide profiling of native G-quadruplexes with high resolution and specificity. We find that native G-quadruplex signals are cell-type specific and are associated with transcriptional regulatory elements with active epigenetic modifications. Promoter-proximal RNA polymerase II pausing promotes native G-quadruplex formation, oppositely, G-quadruplex stabilization by quadruplex-targeted ligands globally reduces RNA polymerase II occupancy at gene promoters as well as nascent RNA synthesis. Moreover, G-quadruplex stabilization modulates chromatin states and impedes transcription initiation via inhibiting the loading of general transcription factors to promoters.Together, these studies reveal a reciprocal regulation between native G-quadruplex dynamics and gene transcription in the genome, which will deepen our knowledge of G-quadruplex biology towards considering therapeutically targeting G-quadruplexes in human diseases.

2021-07-19 | GSE178668 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data