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Transcriptomic profile of zebrafish liver cells in thioacetamide (TAA) model

ABSTRACT: Transcriptomic profile of zebrafish liver cells in thioacetamide (TAA) model

PROVIDER: PRJNA607563 | ENA |

REPOSITORIES: ENA

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Transcriptomic profile of zebrafish liver cells in thioacetamide (TAA) model

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Genome-wide chromatin accessibility profiles of zebrafish liver cells in thioacetamide (TAA) model

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A time-course study of thioacetamide (TAA)-induced liver fibrosis in rats

Project description:The aim is to characterize rat liver fibrosis induced by thioacetamide (TAA). To induce hepatic fibrosis, Male Sprague Dawley rats (9-12 weeks of age and 380-420 g of weight upon arrival, supplied by Beijing Vital River laboratory animal Co., Ltd.) were treated with thioacetamide (TAA). Rat liver samples were collected from five groups of rats at week 1, 2, 4, 8 and 13 after TAA (300 mg/kg) administration three times per week while five control groups receive the same volume of 0.9% normal saline. Four biological replicates were used for each group.

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Genome-wide chromatin accessibility profiles of zebrafish liver cells in thioacetamide (TAA) model

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Project description:Genome-wide chromatin accessibility and transcriptome profiles of zebrafish liver cells in thioacetamide (TAA) model

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Project description:In this study, we investigated the effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model as vitamin D is known to have a spectrum of anticancer activities. Using PET, we found that tumor formation and progression were suppressed in rats fed a diet supplemented with 6 IU/g vitamin D3(+6D) as compared to the group fed a 2 IU/g vitamin D3 diet (+2D) or controls. Microarray analysis of the tumors that arose revealed that vitamin D supplementation caused significant up- and down regulation in 21 and 16 genes, respectively. There are 9 tissue samples (3 rats in each group labeled as (+6), (+2) and control). Duplicate analysis were used for each sample.

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Genome-wide chromatin accessibility and transcriptome profiles of zebrafish liver cells in thioacetamide (TAA) model

Project description:This SuperSeries is composed of the SubSeries listed below.

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