Project description:Bacillus thuringiensis israelensis (Bti) toxins are increasingly used for mosquito control, but little is known about the precise mode of action of each of these toxins, and how they interact to kill mosquito larvae. By using RNA sequencing, we investigated change in gene transcription level and polymorphismvariations associatedwith resistance to each Bti Cry toxin and to the full Bti toxin mixture in the dengue vector Aedes aegypti. The upregulation of genes related to chitin metabolismin all selected strain suggests a generalist, non-toxin-specific response to Bti selection in Aedes aegypti. Changes in the transcription level and/or protein sequences of several putative Cry toxin receptors (APNs, ALPs, α-amylases, glucoside hydrolases, ABC transporters) were specific to each Cry toxin. Selective sweeps associated with Cry4Aa resistancewere detected in 2 ALP and 1 APNgenes. The lack of selection of toxin-specific receptors in the Bti-selected strain supports the hypothesis that Cyt toxin acts as a receptor for Cry toxins in mosquitoes.

2019-05-16 | E-MTAB-7970 | biostudies-arrayexpress

Complete Genome Sequence of Bacillus thuringiensis Serovar Israelensis Strain HD-789.

Project description: Not available

| S-EPMC3853066 | biostudies-literature

VCRC Longitudinal Protocol for Polyarteritis Nodosa - VCRC 5504

Project description:VCRC Longitudinal Protocol for Polyarteritis Nodosa - VCRC 5504

| PRJNA188261 | ENA

VCRC Longitudinal Protocol for Takayasu's Arteritis - VCRC 5503

Project description:VCRC Longitudinal Protocol for Takayasu's Arteritis - VCRC 5503

| PRJNA188259 | ENA

Complete Sequences of Two Plasmids Found in a Brazilian Bacillus thuringiensis Serovar israelensis Strain.

Project description: Not available

| S-EPMC6395864 | biostudies-literature

Comparative genomic analysis and mosquito larvicidal activity of four Bacillus thuringiensis serovar israelensis strains.

Project description: Not available

| S-EPMC7099026 | biostudies-literature

genome sequence for Bacillus thuringiensis sv. israelensis strain AR23

Project description:Characterization and whole genome sequencing of a new highly toxic Bacillus thuringiensis sv. israelensis strain AR23 isolated from Lebanese soil.

| PRJEB28570 | ENA

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