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β-catenin inhibits adipogenic differentiation of hypertrophic chondrocytes and promote osteogenesis

ABSTRACT: β-catenin inhibits adipogenic differentiation of hypertrophic chondrocytes and promote osteogenesis

PROVIDER: PRJNA609317 | ENA |

REPOSITORIES: ENA

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β-catenin inhibits adipogenic differentiation of hypertrophic chondrocytes and promote osteogenesis

Project description:It has been shown that hypertrophic chondrocyte (HC) can become osteoblast, contributing to the formation of trabecular bone and endosteum. However, it is unclear what genes regulate the process of differentiation from chondrocyte to osteoblast. Conditional knock-out of β‑catenin in HCs can reduce the trabecular bone amount and there is also some evidence that ablation of β‑catenin in HCs can promote bone marrow adipogenesis. Conditional stabilization of β‑catenin in HCs results in osteopetrosis. In order to investigate the gene regulatory network with different dosage of β‑catenin in HC descendants (i.e. in Loss-of-Function mutant, Gain-of-Function mutant and Wildtype control), we collected HC descendant cells from proximal tibia of mice at postnatal day 5 and performed bulk RNA seq to profile the gene expression pattern in HC descendants.

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Transcription profiling of chicken proliferative and hypertrophic chondrocytes

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Round or columnar and hypertrophic chondrocytes of Tric-b-KO mice

Project description:To survey altered gene expreesion in round, colmnar and hypertrophic chondrocytes of Tric-b-KO mice, total RNA preparations from round chondrocytes and colmnar/hypertrophic chondrocytes were subjected to gene microarray analysis. Results provide insight into the transcriptional profile of each Tric-b-KO chondrocyte and provide further insight into their functions.

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Bovine Hypertrophic Growth Plate Chondrocytes vs. Reserve Zone Chondrocytes

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Epigenetic mechanisms mediating the transition from proliferating into hypertrophic chondrocytes. [RNA-Seq]

Project description:Correlation of RNA-seq and ChIP-seq data from proliferating (PC) and hypertrophic chondrocytes (HC).

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Epigenetic mechanisms mediating the transition from proliferating into hypertrophic chondrocytes. [ChIP-Seq]

Project description:Chromatin Immunopreciptiation of histone modifications in primary proliferating (PC) and hypertrophic chondrocytes (HC) from embryonic mice

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Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

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