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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (RNA-Seq)

ABSTRACT: Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (RNA-Seq)

PROVIDER: PRJNA611580 | ENA |

REPOSITORIES: ENA

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

Project description:Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (ChIP-Seq)

Project description:Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (ChIP-Seq)

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (ChIP-Seq)

Project description:NF-κB-mediated signaling is maintained silent by the action of IκB proteins, whose canonical role is to sequester NF-κB in the cytoplasm. An alternative chromatin role for IκB members have been shown to affect stemness and cell differentiation but the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB-1 are IκB homologs in Caenorhabditis elegans, which lacks NF-κB nuclear effectors. nfki-1 and ikb-1 mutants present developmental defects that phenocopy mutations in Polycomb genes and demethylases as utx-1. suggesting a role for C. elegans IKB proteins in chromatin regulation, which is supported by various lines of evidence:(i) we detected NFKI-1 in the nucleus; (ii) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (iii) NFKI-1 and IKB-1 bind to chromatin in vivo, and (iv) mutations in nfki-1 and ikb-1 alter chromatin marks . Thus, ancestral IκB inhibitors may exert nuclear functions regulating of gene expression and development.

2020-09-01 | GSE146652 | GEO

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (RNA-Seq)

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

Project description:This SuperSeries is composed of the SubSeries listed below.

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development.

Project description: Not available

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Function, targets and evolution of Caenorhabditis elegans piRNAs

Project description:This SuperSeries is composed of the following subset Series: GSE28617: Function, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq) GSE37432: Function, targets and evolution of Caenorhabditis elegans piRNAs (mRNA) Refer to individual Series

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Project description:This dataset consists of 20 proteomics raw files of two Caenorhabditis elegans strains: N2 and CB4856 under two conditions.

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