Project description:RNA-seq analysis of sorted 6419c5 mouse pancreatic tumor cells from subcutaneously implanted mouse pancreatic tumors with or without treatment of a combination immunotherapy
Project description:Pancreatic cancer is largely refractory to immunotherapies. This project utilized mouse pancreatic tumor cell line to study tumor cell intrinsic mechanisms undelrying resistance to immunotherapies. RNA-seq analysis revealed that immunotherapy-resistant tumor cells exhibit increased gene expression signature of epithelial-to-mesenchymal transition, compared to the parental tumor cells.