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Transcriptional profile of the CNS of pups from Zika virus-infected SJL mothers treated with nanoliposomes loaded with AHR antagonist CH223191

ABSTRACT: Transcriptional profile of the CNS of pups from Zika virus-infected SJL mothers treated with nanoliposomes loaded with AHR antagonist CH223191

PROVIDER: PRJNA613035 | ENA |

REPOSITORIES: ENA

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Transcriptional profile of the CNS of pups from Zika virus-infected SJL mothers treated with nanoliposomes loaded with AHR antagonist CH223191

Project description:SJL pregnant mice were infected with Zika virus and treated with nanoliposomes loaded with AHR antagonist CH223191 or control nanoliposomes. RNA-Seq analysis was performed in CNS samples from the pups.

2020-04-13 | GSE147094 | GEO

Maternal IgG Affects Brain Development of Mouse Pups

Project description:Maternal IgG is an immunoglobulin present in breast milk and has been shown to play a role in the development of the immune system in infants. The aim of this study was to investigate the effects of maternal IgG on brain development in mouse pups. Maternal IgG immunoreactivity was observed in microglial cells of the pup brain, peaking at postnatal 8 day. In particular, strong IgG immunoreactivity was observed in the microglia in the corpus callosum and cerebellar white matter. IgG stimulation of primary cultured microglia resulted in activation of the type I interferon feedback loop by Syk. Among the IgG subclasses, IgG2a was found to have a strong influence on microglia. Analysis of FcRn KO mice that were unable to take up IgG from their mothers revealed that these mice had abnormalities in the proliferation and/or survival of microglia, oligodendrocytes, and some types of interneurons. FcRn KO mice also exhibited abnormalities in social behavior and adaptation to novel environments. This study suggests that maternal IgG affects brain development in pups.

2024-05-24 | GSE248310 | GEO

SJL, Balb: Leg and Eye, 10/12 months

Project description:SJL & Balb. Leg and eye; 1 year, 10 months Keywords: time-course

2004-08-02 | GSE1092 | GEO

Effect of gut microbiome transplant from neonates of particle-exposed mothers on the epigenome of dendritic cells

Project description:In our model the newborns of asthmatic mother mice or of mothers exposed to air pollutant particles are born with a predisposition to asthma. Gut microbiome of these pups is altered, and the transplant of the pups’ microbiome (GMT) has conferred the asthma predisposition to naïve recipients. We hypothesized that bacteria alter metabolomic profile in the gut, which polarizes the dendritic cells (DC) in the recipient by affecting epigenetic regulation in these key decision-maker cells. Here we examined DNA methylation profiles in the recipient host’s DCs to test the prediction that GMT confers alterations in DNA methylation (not seen with sterilized GMT).

2024-04-01 | GSE247470 | GEO

Mus musculus strain:SJL

Project description:Mus musculus strain:SJL Raw sequence reads

| PRJNA683892 | ENA

AhR antagonist

Project description:AhR antagonist

| PRJNA766233 | ENA

Identification of gene expression patterns in lymphoma-prone SJL mice of different ages

Project description:SJL mice spontaneously develop mature B cell lineage lymphomas. These studies were designed to evaluate significant gene expression differences between spleens of control mice that do not develop lymphomas compared to spleens from SJL mice of differeing ages

2015-12-31 | GSE57150 | GEO

AhR antagonist

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-01 | GSE184780 | GEO

mRNA Sequencing of pups heart Knock-in Mfn2R400Q

Project description:We sequencing E18.5 pups heart carryng human Mfn2mutantion vs Ctrl mouse and we found different RNA profile

2023-10-31 | GSE214984 | GEO

Colonic tissues from an acute TNBS-induced colitis model in SJL mice.

Project description:Experimental colitis is often used as a model for the inflammatory bowel diseases, ulcerative colitis and Crohn’s disease. Results identify the inflammatory processes during acute colitis in affected tissues from TNBS-treated susceptible 5-7 week old SJL mice. Keywords: Disease state analysis

2008-09-08 | GSE12139 | GEO

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