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Transcriptional modifications driven by STING activation in polarizing TH1 and Th9 cells

ABSTRACT: Transcriptional modifications driven by STING activation in polarizing TH1 and Th9 cells

PROVIDER: PRJNA613701 | ENA |

REPOSITORIES: ENA

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Transcriptional modifications driven by STING activation in polarizing TH1 and Th9 cells

Project description:We assessed the global transcriptional changes driven by STING activation with the cyclic dinucleotide 2'3'-cGAMP TH1 and TH9 cells polarized in vitro for 16h and 48h. Our data indicated that STING activation led to an upregulation of Type I Interferon, Interferon Stimulated Genes and pro-inflammatory molecule production that was maintained over time. Furthermore, not only STING activation enhanced the transcription of TH1 and TH9 main effector cytokines (respectively Ifng and Il9) but they also also globally enhanced their differentiation programs.

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The transcription factor BATF3 regulates the differentiation of TH9 cells and TH9-driven mucosal pathologies

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Transcriptional profiling of Th1, Th2, Th9, and Th17 T cell clones

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