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Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [I]

ABSTRACT: Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [I]

PROVIDER: PRJNA622526 | ENA |

REPOSITORIES: ENA

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Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Project description:Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

| PRJNA622522 | ENA

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [II]

Project description:Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [II]

| PRJNA622525 | ENA

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses.

Project description: Not available

| S-EPMC7398161 | biostudies-literature

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-04-02 | GSE147908 | GEO

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [II]

Project description:Temporal transcriptome profiling of TCR-reactivated (P14) and bystander-reactivated (OT-I) memory T cells in the lung and mediastinal lymph node based on Nur77-GFP reporter expression and CD98 expression

2020-04-02 | GSE147907 | GEO

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [I]

Project description:Global profiling to investigate the consequence of the lack of TAP-1 on hematopoetic cell or non-hematopoetic cell on the qualitative response of reactivated antigen-specific Trm cells

2020-04-02 | GSE147906 | GEO

Antigen Presenting Dendritic Cells

Project description:Assessing the gene expression repertoire of antigen presenting dendritic cells Keywords: other

2004-09-30 | GSE702 | GEO

Antigen presenting cells of myeloid origin

Project description:Transcriptional profiles of four different myeloid antigen presenting cell (APC) subsets (BDCA-1+ circulating myeloid dendritic cells, CD14+ monocytes, and in vitro generated immature and mature monocyte-derived dendritic cells) were used for comprehensive transcriptome analysis. Based on the gene expression profiling data, a quantitative relationship between myeloid APC in functionally related gene spaces was established. Keywords = myeloid antigen presenting cells Keywords = dendritic cell subsets Keywords: repeat sample

2017-12-21 | GSE2215 | GEO

Assessment of genome-wide chromatin accessibility of subsets of bone marrow-resident antigen presenting cells [ATAC_BMACs]

Project description:Chromatin accessibility of bone marrow-resident Aire expressing cells was compared to those of bone marrow plasma cells and B cells via ATAC-seq Bone marrow (BM) harbors a large repertoire of regulatory T (Treg) cells, which are essential in hematopoiesis and peripheral tolerance. Treg cell accumulation in BM has been viewed as a consequence of preferential immigration of thymus-derived Treg cells. Here we report a novel subset of antigen presenting cells, which expresses the autoimmune regulator (Aire). These BM Aire-expressing cells resemble a subset of CD138+B220-TACI+Blimp-1+MHC-II+ plasma cells (pc-BMACs) and express a diverse repertoire of tissue-restricted self-antigens. pc-BMACs present self-antigens to na ve CD4+ T cells and can efficiently convert these into functionally competent CD25+Foxp3+ bona fide peripheral Treg cells (pTregs) capable of exerting immune suppression in vitro and in vivo. Aire expression may contribute to the tolerogenic function of pc-BMACs as it regulates the expression of genes involved in pTreg induction and function, including Icosl and retinoic acid synthesis-related genes, Aldh1a2 and Aldh1b1. Our data thus demonstrate an Aire-expressing plasma cell subset in the BM capable to promote peripheral tolerance by ectopically expressing tissue-restricted self-antigens and generating pTregs.

2022-08-26 | GSE136649 | GEO

Delineating Tumor-infiltrating Antigen Presenting Cell populations

Project description:The goal of this study is to compare tumor-infiltrating antigen presenting cell populations by global transcriptome profiling (RNA-seq) to help further delineate sub-populations of infiltrating myeloid cells in tumor. Methods: Four tumor antigen presenting cell populations were sorted from digested B78chOVA (melanoma variant) tumors in biological triplicate Results: RNA was extracted from the 4 groups (n=3 per group) and prepared for RNAseq. Sequencing yielded ~405 million reads with an average read depth of 33.7 million reads/sample. Reads were then aligned to the mouse genome (UCSC mm10) and those that mapped uniquely to known mRNAs were used to assess differential expression.

2014-11-10 | GSE61462 | GEO

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