Genomics

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Neuron-derived exosome from plasma show altered miRNA cargo as a function of antidepressant drug response.


ABSTRACT: Neuron-derived exosome from plasma show altered miRNA cargo as a function of antidepressant drug response.

PROVIDER: PRJNA625058 | ENA |

REPOSITORIES: ENA

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Publications

Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response.

Saeedi Saumeh S   Nagy Corina C   Ibrahim Pascal P   Théroux Jean-Francois JF   Wakid Marina M   Fiori Laura M LM   Yang Jennie J   Rotzinger Susan S   Foster Jane A JA   Mechawar Naguib N   Kennedy Sidney H SH   Turecki Gustavo G  

Molecular psychiatry 20210812 12


Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how representative these peripherally detected miRNA changes are to those occurring in the brain. This study aimed to use peripherally extracted neuron-derived extracellular vesicles (NDEV) to circumvent these limitations and investigate neuronal miRNA changes associated with antidepressant response. Samples were collected at two time points (baseline and  ...[more]

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