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Interferons disrupt lung epithelial repair during recovery from respiratory infection

ABSTRACT: Interferons disrupt lung epithelial repair during recovery from respiratory infection

PROVIDER: PRJNA625478 | ENA |

REPOSITORIES: ENA

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Interferons disrupt lung epithelial repair during recovery from respiratory infection [RN19197]

Project description:Interferons disrupt lung epithelial repair during recovery from respiratory infection [RN19197]

| PRJNA625462 | ENA

Interferons disrupt lung epithelial repair during recovery from respiratory infection [RN200717]

Project description:Interferons disrupt lung epithelial repair during recovery from respiratory infection [RN200717]

| PRJNA625463 | ENA

Interferons disrupt lung epithelial repair during recovery from respiratory infection [RN200717]

Project description:Respiratory viral infections cause lung epithelial damage, barrier dysfunction and severe disease. Type I interferons (IFN-a/b) are antiviral cytokines whose therapeutic use is limited by well-characterized pleiotropic effects. Type III IFNs (IFN-λ) are less pro-inflammatory and regarded a superior treatment option. Here, we show that IFN signalling reduces lung epithelial proliferation and differentiation and increases epithelial apoptosis during recovery from viral infection. This delays epithelial repair, increasing disease severity and the risk of bacterial superinfection. IFN-a has least effects, with IFN-b intermediate and IFN-λ strongest action.

2020-06-12 | GSE148710 | GEO

Interferons disrupt lung epithelial repair during recovery from respiratory infection [RN19197]

2020-06-12 | GSE148709 | GEO

Interferons disrupt lung epithelial repair during recovery from respiratory infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-06-12 | GSE148712 | GEO

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.

Project description: Not available

| S-EPMC7292500 | biostudies-literature

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes

Project description:The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction with slow recovery and TC-NER at the 3’ end of long genes. RNA synthesis resumed fully at the 3’-end of genes after a 24-hour recovery in wild-type fibroblasts, but not in cells deficient in transcription-coupled nucleotide excision repair (TC-NER) or global genomic NER (GG-NER). Different transcription recovery profiles were found for individual genes but these differences did not fully correlate to differences in DNA repair of these genes. Our study gives the first genome-wide view of how UV-induced lesions affect transcription and how the recovery of RNA synthesis of large genes are particularly delayed by the apparent lack of resumption of transcription by arrested polymerases. This study is composed of three identical experiments run in three different cell lines. For each experiment, there is one control (mock irradiated cells) and four test samples (0h, 2h, 6h and 24h after UV 10J irradiation).

2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress

Eutherian interferons

Project description:Eutherian interferons

| PRJEB36709 | ENA

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes

2015-03-03 | GSE65985 | GEO

Transcription profiling of peripheral blood leukocyte genomic response one day post traumatic injury may predict early respiratory recovery

Project description:This data was used as an example to illustrate a computational method for assessing statistical significance in microarray experiments Contributed by 'The Inflammation and the Host Response to Injury Collaborative Research Program.' Keywords: Two group comparison Genomic response one day post traumatic injury was compared between patients having early or late respiratory recovery

2011-12-01 | E-GEOD-13488 | biostudies-arrayexpress

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