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Shock waves induce an evolutionary conserved mechanism of spinal cord regeneration via Toll-like receptor 3

ABSTRACT: Shock waves induce an evolutionary conserved mechanism of spinal cord regeneration via Toll-like receptor 3

PROVIDER: PRJNA628694 | ENA |

REPOSITORIES: ENA

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Shock waves induce an evolutionary conserved mechanism of spinal cord regeneration via Toll-like receptor 3

Project description:Shock wave therapy (SWT) is improving motor function and decreasing lesion size in wild-type but not Tlr3-/- mice via IL6 dependent differentiation of neuronal progenitor cells. Both SWT and TLR3 stimulation enhance neuronal sprouting and survival, even in human spinal cord cultures. We could also identify tlr3 as a crucial enhancer of spinal cord generation in zebrafish. In order to substantiate underlying mechanisms of the SWT for spinal cords, cultured human neurons (neuroblastoma cell line) were treated with SWT and gene expression profiling were performed by RNAseq.

2020-09-08 | GSE149446 | GEO

Shock waves promote spinal cord repair via TLR3.

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Combinatorial therapies for spinal cord injury: strategies to induce regeneration.

Project description: Not available

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Diet, Genes and Colorectal Cancer - With Focus on Toll-like Receptor Polymorphisms

Project description:The aim of this study is to investigate the interaction between diet - primary meat and fiber - and polymorphisms in Toll-like receptors in relation to risk of colorectal cancer in a Danish prospective cohort.

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Expression pattern of Pseudomonas aeruginosa biofilm-residing bacteria exposed to gentamicin or surface acoustic waves or gentamicin and surface acoustic waves combined

Project description:Bacteria are known to respond to various environmental stimuli including nutrient deprivation, osmotic stress, and exposure to antibiotics. Our experimental data showed that P. aeruginosa biofilm formed in urinary catheters is very suseptible to gentamicin treatment when combined with exposure to surface acoustic waves Our goal was to establish whether P. aeruginosa is capable of specifically sensing the surface acoustic waves as well as to try and decipher the molecular mechanism underlying the increased biofilm suseptibility to antibiotics treatment

2011-09-01 | GSE28081 | GEO

Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry

Project description:Tissue morphogenesis requires the spatial control over actomyosin contractility to drive cell shape changes. How developmental patterning information controls cell mechanics is poorly understood. In the Drosophila embryo ectoderm, Myosin-II is enriched at the interface between antero-posterior neighboring cells, leading to planar polarized cell intercalation. G protein-coupled receptors (GPCRs) are required for planar polarized Myosin-II activation at junctions and Toll receptors provide a positional code underlying this process. How Toll receptors polarize actomyosin contractility remains unknown. Here we report that cells expressing different levels of a single Toll receptor Toll-8 activate Myosin-II at their interface. Surprisingly, the Toll-8 intracellular domain is not required for signaling at cell interfaces suggesting signaling by proxy. We found that Toll-8 forms a molecular complex with the adhesion GPCR Cirl/Latrophilin that is required for Toll-8 dependent junctional Myosin-II activation. Strikingly, the interfaces between Cirl expressing and cirl mutant cells also activate Myosin-II suggesting that Toll-8 induces Cirl asymmetric signaling at cell interfaces. We further showed that Toll-8 recruits Cirl both in trans and in cis, inducing asymmetric Cirl localization at the boundary of the Toll-8 expression domain. Finally, we found that Toll-8 and Cirl exhibit dynamic interdependent planar polarization when neighboring cells express different levels of Toll-8. Through this feedback, Toll-8 and Cirl self-organize planar polarized signaling.

2021-04-22 | PXD017895 | Pride

Purinergic junctional transmission and propagation of calcium waves in cultured spinal cord microglial networks.

Project description: Not available

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Proteomic Portraits Reveal Evolutionarily Conserved and Divergent Responses to Spinal Cord Injury.

Project description: Not available

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Sequential Waves of Protein Phosphorylation Functionally Rewire the Proteome to Drive Gametogenesis

Project description:Using phosphoproteomics, we show that regulated waves of protein phosphorylation affect virtually all cellular functions to supoort meiotic entry, meiotic progeression and gamete morphogenesis.

2022-12-13 | PXD033675 | Pride

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