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ACVR2B antagonism preserves skeletal muscle and cardiac function in metastatic colorectal cancer

ABSTRACT: ACVR2B antagonism preserves skeletal muscle and cardiac function in metastatic colorectal cancer

PROVIDER: PRJNA629345 | ENA |

REPOSITORIES: ENA

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ACVR2B antagonism preserves skeletal muscle and cardiac function in metastatic colorectal cancer

Project description:Advanced colorectal cancer remains a leading cause of death worldwide and is often accompanied by the development of liver metastases, as well as cachexia, a multi-organ wasting syndrome inclusive of both skeletal and cardiac muscle. Activin receptor type 2B (ACVR2B)-mediated signaling participates in causing skeletal wasting in several disease conditions, and its inhibition restores skeletal muscle mass and prolongs survival in cancer cacehxia. Here we wanted to asses whether ACVR2B antagonism could preserve skeletal and cardiac muscle mass and function in a model of metastatic colorectal cancer.

2020-11-17 | GSE149604 | GEO

Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism

Project description:The growing field of cardio-oncology addresses the side effects of cancer treatment on the cardiovascular system. Here, we explored the cardiotoxicity of the antiangiogenic therapy, sunitinib, in the mouse heart from a diagnostic and therapeutic perspective. We showed that sunitinib induces an anaerobic switch of cellular metabolism within the myocardium which is associated with the development of myocardial fibrosis and reduced left ventricular ejection fraction as demonstrated by echocardiography. The capacity of positron emission tomography with [18F]fluorodeoxyglucose to detect the changes in cardiac metabolism caused by sunitinib was dependent on fasting status and duration of treatment. Pan proteomic analysis in the myocardium showed that sunitinib induced (i) an early metabolic switch with enhanced glycolysis and reduced oxidative phosphorylation, and (ii) a metabolic failure to use glucose as energy substrate, similar to the insulin resistance found in type 2 diabetes. Co-administration of macitentan, the endothelin receptor antagonist, to sunitinib-treated animals prevented both metabolic defects, restored glucose uptake and cardiac function, and prevented myocardial fibrosis. These results support the endothelin system in mediating the cardiotoxic effects of sunitinib and endothelin receptor antagonism as a potential therapeutic approach to prevent cardiotoxicity. Furthermore, metabolic and functional imaging can monitor the cardiotoxic effects and the benefits of endothelin antagonism in a theranostic approach.

2017-07-14 | PXD006888 | Pride

Cardiac response to thromboxane-prostanoid receptor antagonism in a mouse model of muscular dystrophy

Project description:Cardiac response to thromboxane-prostanoid receptor antagonism in a mouse model of muscular dystrophy

| PRJNA493798 | ENA

Cardiac response to thromboxane-prostanoid receptor antagonism in a mouse model of muscular dystrophy

Project description:Expression analysis of left ventricle taken from wildtype or delta-sarcoglycan knockout mice, a model of muscular dystrophy. Mice were treated from weaning with vehicle or the thromboxane-prostanoid (TP) receptor antagonist ifetroban. Results provide insight into effects of TP receptor antagonism on cardiomyopathy of muscular dystrophy.

2021-09-28 | GSE120625 | GEO

Proteomic characterization of metastatic colorectal cancer

Project description:To characterize metastatic progression of colorectal cancer, we performed mass spectrometry-based proteome analysis using large clinical cohort samples.

2024-01-16 | PXD031705 | Pride

Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.

Project description: Not available

| S-EPMC2639131 | biostudies-literature

hepatic metastatic colorectal cancer gene expression array

Project description:The goal of this experiment was to build gene expression signature associated with long-term outcomes of patients with hepatic metastatic colorectal cancer. The samples were corrected from surgically resected liver metastasis and extracted RNA was subjected to Illumina expression gene chip analysis.

2014-01-14 | E-MTAB-1951 | biostudies-arrayexpress

Understanding the progression of metastatic colorectal cancer

Project description:Understanding the progression of metastatic colorectal cancer

| PRJNA498172 | ENA

Understanding the progression of metastatic colorectal cancer

Project description:Understanding the progression of metastatic colorectal cancer

| PRJNA498173 | ENA

Glucocorticoids and estrogen antagonism in cardiomyocytes

Project description:Glucocorticoids and estrogen antagonism in cardiomyocytes negatively influences cell survival in the female heart after MI by a mechanism involving GR inhibition of ERalpha-dependent transcriptional regulation.

2021-01-10 | GSE143461 | GEO

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