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Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria.


ABSTRACT: Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria.

PROVIDER: PRJNA632548 | ENA |

REPOSITORIES: ENA

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Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria.

Nahrendorf Wiebke W   Ivens Alasdair A   Spence Philip J PJ  

eLife 20210323


Immunity to malaria is often considered slow to develop but this only applies to defense mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe disease can be acquired quickly and without the need for improved pathogen control (tolerance). Using <i>Plasmodium chabaudi</i>, we show that a single malaria episode is sufficient to induce host adaptations that can minimise inflammation, prevent tissue damage and avert endothelium activation, a hallmark of severe  ...[more]

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