Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tetracentron sinense isolate:Mount Emei Botanical Garden

ABSTRACT: Tetracentron sinense isolate:Mount Emei Botanical Garden Genome sequencing and assembly

PROVIDER: PRJNA636923 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Camellia nitidissima isolate:Guangxi Medicinal Botanical Garden

Project description:Camellia nitidissima isolate:Guangxi Medicinal Botanical Garden Genome sequencing

| PRJNA472131 | ENA

Magnolia shiluensis cultivar:South China Botanical Garden

Project description:Magnolia shiluensis cultivar:South China Botanical Garden Genome sequencing and assembly

| PRJNA561049 | ENA

Integrated network pharmacology and cellular assay reveal the biological mechanisms of Limonium sinense (Girard) Kuntze against breast cancer

Project description:Limonium Sinense (Girard) Kuntze (L. sinense) has been widely used for the treatment of anaemia, bleeding, cancer, and other disorders in Chinese folk medicine. The aim of this study is to predict the therapeutic effects of L. sinense and investigate the potential mechanisms using integrated network pharmacology methods and in vitro cellular experiments. A total of 15 active ingredients of L. sinense and their corresponding 389 targets were obtained. KEGG enrichment analysis revealed that the biological effects of L. sinense were primarily associated with Pathways in cancer. DisGeNET enrichment analysis highlighted the potential role of L. sinense in the treatment of breast cancer. Cellular experiments demonstrated that the L. sinense ethanol extract (LSE) exhibited a significant growth inhibitory effect on multiple breast cancer cell lines in both 2D and 3D cultures. This study predicts the biological activities of L. sinense and demonstrates the inhibitory effect of LSE on breast cancer cells, highlighting the potential application of L. sinense in cancer treatment.

2023-11-08 | GSE244469 | GEO

Burkholderia vietnamiensis strain:Garden Soil | isolate:Garden Soil

Project description:Burkholderia vietnamiensis strain:Garden Soil | isolate:Garden Soil Genome sequencing

| PRJNA660427 | ENA

Cymbidium sinense isolate:YW-2021

Project description:Cymbidium sinense isolate:YW-2021 Genome sequencing and assembly

| PRJNA743748 | ENA

Chloranthus sessilifolius isolate:Mount Emei

Project description:Chloranthus sessilifolius isolate:Mount Emei Genome sequencing and assembly

| PRJNA759285 | ENA

Cymbidium sinense

Project description:Cymbidium sinense overview

| PRJNA174695 | ENA

Ligusticum sinense

Project description:Ligusticum sinense overview

| PRJNA483813 | ENA

Trichoderma sinense

Project description:Trichoderma sinense overview

| PRJNA622356 | ENA

Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation

Project description:Limonium Sinense (Girard) Kuntze is a traditional Chinese medicinal herb, showing blood replenishment, anti-tumour, anti-hepatitis, and immunomodulation activities amongst others. However, the mechanism of its pharmacological activities remains largely unknown. Here, we investigated the effects of bioactive ingredients from Limonium Sinense using integrated analysis. Water extracts from Limonium Sinense (LSW) showed a strong growth inhibitory effect on multiple cells in both 2D and 3D cultures. Global transcriptomic profiling and further connectivity map (CMap) analysis identified several similarly acting therapeutic candidates, including Tubulin inhibitors and hypoxia-inducible factor (HIF) modulators. The effect of LSW on cell cycle was verified with flow cytometry showing a G2/M phase arrest. Integrated analysis suggested a role for gallic acid in mediating HIF activation. Taken together, this study provides novel insights into the bioactive ingredients in Limonium Sinense, highlighting the rich natural resource and therapeutic values of herbal plants.

2022-09-29 | GSE205252 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data