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A comprehensive transcriptome profiling in inclusion body myositis [miRNA-Seq]

ABSTRACT: A comprehensive transcriptome profiling in inclusion body myositis [miRNA-Seq]

PROVIDER: PRJNA637097 | ENA |

REPOSITORIES: ENA

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A comprehensive transcriptomic profiling in inclusion body myositis

Project description:A comprehensive transcriptomic profiling in inclusion body myositis

| PRJNA637095 | ENA

A comprehensive transcriptome profiling in inclusion body myositis [RNA-Seq]

Project description:A comprehensive transcriptome profiling in inclusion body myositis [RNA-Seq]

| PRJNA637096 | ENA

Plasma Cells in Muscle in Inclusion Body Myositis and Polymyositis

Project description:Microarray data from muscle biopsy specimens from subjects with inclusion body myositis, polymyositis, and normals Keywords: Research study

2005-10-01 | GSE3112 | GEO

Transcription profiling of human plasma cells in muscle in inclusion body myositis and polymyositis

Project description:Microarray data from muscle biopsy specimens from subjects with inclusion body myositis, polymyositis, and normals Experiment Overall Design: Microarray experiments

2008-06-12 | E-GEOD-3112 | biostudies-arrayexpress

inclusion body myositis

Project description:We investigated the gene and exon espression profiling in muscle biopsies of patients affected by inclusion body myosistis, polymyositis and in normal muscle controls

2014-02-02 | E-MTAB-2141 | biostudies-arrayexpress

Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis

Project description:Myositis is characterised by muscle inflammation and weakness. Although generally thought to be driven by a systemic autoimmune response, increasing evidence suggests that intrinsic changes in the muscle might also contribute to the pathogenesis. Long non-coding RNAs (lncRNAs) are a family of novel genes that regulate gene transcription and translation. To determine the potential role of lncRNAs, we employed next generation sequencing to examine the transcriptome in muscle biopsies obtained from two histologically distinct patient populations, inclusion body myositis (IBM) and anti-Jo-1-associated myositis (Jo-1).

2017-08-02 | GSE102138 | GEO

Myositis muscle

Project description:Expression profiling of human myositis muscle samples This study was designed to compare expression signatures among the various types of inflammatory myopathy, dermatomyositis (DM), inclusion body myositis (IBM), necrotizing myopathy (NM), nonspecific myopathy (NS), and polymyositis (PM) compared to normal (NL) muscle.

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A comprehensive transcriptome profiling in inclusion body myositis [miRNA-Seq]

Project description:Profiling of miRNA RNA in IBM muscles.

2021-07-01 | GSE151756 | GEO

Plasma cell infiltrate populating the muscle tissue of patients with inclusion body myositis feature distinct BCR repertoire properties

Project description:Inclusion body myositis (IBM) is an autoimmune and degenerative disorder of skeletal muscle. The B cell infiltrates in IBM muscle tissue are predominantly fully differentiated antibody-secreting plasma cells, with scarce naïve or memory B cells. The role of this infiltrate in the disease pathology is not well understood. To better define the humoral response in IBM, we used adaptive immune receptor repertoire sequencing to generate large B cell receptor (BCR) repertoire libraries from IBM muscle biopsies and compared them to those generated from dermatomyositis (DM), polymyositis (PM), and circulating CD27+ memory B cells, derived from healthy controls and antibody secreting cells (ASC) collected following vaccination. The repertoire properties of the IBM infiltrate included: expanded clones that equaled or exceeded the highly clonal vaccine-associated ASC repertoire; reduced somatic mutation selection pressure in the complementary determining regions and framework regions; and enriched usage of class switched IgG and IgA isotypes, with a minor population of IgM expressing cells. These IBM IgM-expressing population revealed unique features, including an elevated somatic mutation frequency and distinct CDR3 physicochemical properties., These findings demonstrate that the IBM muscle BCR repertoire is highly distinct from DM and PM and circulating antigen-experienced subsets, suggesting that it may form through selection by a disease-specific set of antigens.

2023-04-25 | GSE227124 | GEO

A comprehensive transcriptomic profiling in inclusion body myositis

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-01 | GSE151758 | GEO