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Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [scRNA-seq dataset]

ABSTRACT: Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [scRNA-seq dataset]

PROVIDER: PRJNA637579 | ENA |

REPOSITORIES: ENA

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Similar Datasets

Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [bulk RNA-seq dataset)

Project description:Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [bulk RNA-seq dataset)

| PRJNA637580 | ENA

Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages

Project description:Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages

| PRJNA637572 | ENA

Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [scRNA-seq dataset]

Project description:Heart injury has been reported in up to 20% of COVID-19 patients, yet the cause of myocardial histopathology is unknown. We examined heart tissue from autopsies of healthy and COVID-19 patients using RNA-seq and identified a strikingly increased CCL2 expression and macrophage population in COVID-19 heart sample. Transwell assays using hESC-derived cardiomyocytes (CMs) and macrophages revealed that SARS-CoV-2 infected CMs secrete CCL2, which recruits macrophages, and this was validated using adult human CMs. Macrophages recruited by CCL2 from infected CMs secrete IL-6 and TNF-α, which causes increased ROS and cell apoptosis of CMs. Finally, a high content chemical screen using FDA-approved drugs identified ranolozine and tofacitinib, which rescue SARS-CoV-2 infected CMs from macrophages-induced cardiotoxicity.

2020-10-29 | GSE151878 | GEO

Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [bulk RNA-seq dataset)

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Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-29 | GSE151880 | GEO

Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2.

Project description: Not available

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RNA-Seq of Human iPSC-cardiomyocytes infected with SARS-CoV-2

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