Project description:The intestinal microbiome has been associated with response to immune checkpoint inhibitors (ICI) in humans, and causally implicated in ICI responsiveness in animal models. Therapeutic augmentation of the microbiome in ICI recipients is being investigated in multiple ongoing human clinical trials. We conducted an early phase clinical trial of a cultivated, orally-delivered 30-species microbial consortium (microbial ecosystem therapeutic-4, MET4) designed for co-administration with ICIs and assessed safety, tolerability and ecological responses in patients with advanced solid tumors.
Project description:Detection of microorganisms in dune sand of a low organic content
| PRJEB40646 | ENA
Project description:Soil Mineral Composition and Salinity are the Main Factors Regulating Bacterial Community Associated with the Root of Coastal Sand Dune Halophytes
| PRJNA813219 | ENA
Project description:Microbial ecology of a coastal dune chronosequence in New Zealand
