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Identification of 3 Endotypes In Pediatric ARDS Using Nasal Transcriptomics-Low Input

ABSTRACT: Identification of 3 Endotypes In Pediatric ARDS Using Nasal Transcriptomics-Low Input

PROVIDER: PRJNA641110 | ENA |

REPOSITORIES: ENA

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Identification of 3 Endotypes In Pediatric ARDS Using Nasal Transcriptomics-Low Input

Project description:This study used nasal transcriptomic profiling of the inferior turbinate in control and pediatric ARDS subjects to identify endotypes. This data set is for amplified specimens. The study identfied three pediatric ARDS endotypes.

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Identification of 3 Endotypes In Pediatric ARDS Using Nasal Transcriptomics-Standard Input

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methyl-Seq of Pediatric ARDS Nasal and Bronchial Brushings

Project description:The objective of this study was to identify differences in the nasal methylome of patients with Pediatric ARDS (PARDS) compared to controls and to observe how this might change over time. We found two different methylomic patterns. Subgroup 1 was comprised of entirely of PARDS subjects, and Subgroup 2 contained both control and PARDS subject. Subgroup 1was characterized by hypomethylation of genes related to cell adhesion and hypermethylation of cell metabolism-related genes. Over time, the methylation pattern of PARDS subjects changed, but the pattern of control subjects was stable. Five concurrent bronchial and nasal specimens were obtained showing very few differences in methylation between these two collection sites.

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