Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic profiling of murine aneurysm formation after porcine pancreatic elastase infusion

ABSTRACT: Transcriptomic profiling of murine aneurysm formation after porcine pancreatic elastase infusion

PROVIDER: PRJNA641422 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic profiling of murine aneurysm formation after porcine pancreatic elastase infusion

Project description:In the present work, we aimed to investigate the changes in total RNA expression after porcine pancreatic elastase (PPE) instillation in C57BL/6 mice.

2022-01-01 | GSE153097 | GEO

MicroRNA transciptional profiling in murine abdominal aortic aneurysm (AAA), porcine pancreatic elastase (PPE) model - Day 7

Project description:We sought to identify differentially regulated microRNAs in infrarenal mouse aortic tissue after AAA-induction with PPE, compared with sham-operated mice. This treatment leads to rapid development of infrarenal aortic aneurysms with significant diameter differences observed by Day 7. We found 41 miRNAs were up-regulated with aneurysm and 37 down-regulated at p<0.05, which were also altered by >1.5-fold. Utilizing the PPE infusion model, we induced AAA in Male 10-week-old C57/Bl6 mice, 7 days after AAA-induction with PPE. One array per mouse, 5 mice per group, two groups (PPE and sham).

2014-08-31 | E-GEOD-51226 | biostudies-arrayexpress

Lung Immune Cells in Wildtype and Cela1-/- Mice 21 Days After Tracheal Porcine Pancreatic Elastase

Project description:8-10 week old wildtype and Cela1-/- in C57BL6 background were treated with 2 units of tracheal porcine pancreatic elastase or PBS and on day 21 lungs were collected, flow sorted, and libraries created from lung cells of 3 mice per group using 10X Chromium controller and cellplex lipid hashing oligos.

2022-09-23 | E-MTAB-12097 | biostudies-arrayexpress

Mouse and human abdominal aneurysm proteomics

Project description:Aortic tissues of developing and established aneurysms produced by angiotensin II (AngII) infusion were examined in Apoe-/- and Ldlr-/- mice. Aortas were also acquired from wildtype C57BL/6J mice following intraluminal elastase incubation. Aortas were dissected free and separated into eight anatomical segments for proteomics in comparison to their appropriate controls. In addition, proteomics was performed on human infrarenal aortic aneurysm tissues as well as aortic tissue collected from age-matched controls.

2022-08-02 | PXD032293 | Pride

Abdominal Aortic Aneurysm in C57BL/6J Mice - Male and Female PPE vs. Sham Day 7

Project description:Transcriptional profiling of infrarenal aorta from male and female mice (10-weeks old, C57BL/6J), treated with either porcine pancreatic elastase (PPE) local infusion or sham operation (saline infusion). Samples harvested 7 days after treatment. Goal was to examine gene expression in AAA in this model in both genders. Surgical protocol is as described in PMCID: PMC3148686/PMID: 19629030.

2022-03-03 | GSE197748 | GEO

MicroRNA transciptional profiling in murine abdominal aortic aneurysm (AAA), porcine pancreatic elastase (PPE) model - Day 7

2014-08-31 | GSE51226 | GEO

Murine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7

Project description:Transcriptional profiling of infrarenal aortic tissue from Male 10-week-old C57BL/6J mice after AAA-induction with porcine pancreatic elastase, compared with sham-operated mice. Includes samples obtained 7 days after aneurysm induction. Goal was to examine gene expression in developing AAA in this model, and compare with miRNA profiling performed using the same tissue. Two condition experiment, one infrarenal aorta per array. Sham vs. PPE at Day 7 post-operatively. Total 10 arrays: 5 sham D7, 5 PPE D7.

2014-08-31 | E-GEOD-51227 | biostudies-arrayexpress

Murine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7

2014-08-31 | GSE51227 | GEO

Liver transcriptome of an LPS infusion model for porcine sepsis

Project description:Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection. This is best studied in humans and various mouse models, however finding sof these models to not always translate easy to the clinic. In order to improve this transfer, and because sepsis also plays a significant role in vetrenairy medicine, we use the pig as a model organism in sepsis research. We compare two modes of porcine sepsis iduction: fecal infusion and LPS infusion and also compare thse o wha we can find in mice

2023-12-31 | GSE250039 | GEO

Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in a Mouse Cerebral Aneurysm Model

Project description:Cerebral aneurysms were induced in adult male mice using an elastase model. Single-cell RNA sequencing was then performed on circle of Willis samples obtained at 14 days post-aneurysm induction.

2022-07-12 | GSE193533 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data