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Actvity-dependent profiling of lateral septum neurons following restraint stress

ABSTRACT: Actvity-dependent profiling of lateral septum neurons following restraint stress

PROVIDER: PRJNA647373 | ENA |

REPOSITORIES: ENA

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Actvity-dependent profiling of lateral septum neurons following restraint stress

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Effect of chronic restraint stress or repeated activation of PVN neurons responding to restraint stress on gene expression of white adipose tissues (iWAT and eWAT) during adipogenesis of mice

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Project description:Acute stress provides many beneficial effects whereas chronic stress contributes to a variety of human health problems. The objective of this study was to use a rodent model to uncover hippocampal gene signatures associated with prolonged chronic stress which could potentially serve as biomarkers and therapeutic targets for early diagnosis and pharmacological intervention for stress induced disease. Mice were subjected to restraint stress over 7 consecutive days and gene expression changes in the hippocampus were analyzed at 3, 12 and 24 hours following the final restraint treatment. Data indicated that mice exposed to chronic restraint stress exhibit a differential gene expression profile compared to non-stressed controls. The greatest differences were observed 12 and 24 hrs following the final stress test.

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