Genomics

Dataset Information

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MeRIP-seq mapping of m6A in the IFN-β induced transcriptome in Huh7 cells


ABSTRACT: MeRIP-seq mapping of m6A in the IFN-β induced transcriptome in Huh7 cells

PROVIDER: PRJNA649691 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR12350703.fastq.gz Fastqsanger.gz
SRR12350704.fastq.gz Fastqsanger.gz
SRR12350705.fastq.gz Fastqsanger.gz
SRR12350706.fastq.gz Fastqsanger.gz
SRR12350707.fastq.gz Fastqsanger.gz
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Publications


Type I interferons (IFNs) induce hundreds of IFN-stimulated genes (ISGs) in response to viral infection. Induction of these ISGs must be regulated for an efficient and controlled antiviral response, but post-transcriptional controls of these genes have not been well defined. Here, we identify a role for the RNA base modification N6-methyladenosine (m<sup>6</sup>A) in the regulation of ISGs. Using ribosome profiling and quantitative mass spectrometry, coupled with m<sup>6</sup>A-immunoprecipitati  ...[more]

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