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Transcriptomic analysis of mice heart following transverse aortic constriction (TAC) surgery

ABSTRACT: Transcriptomic analysis of mice heart following transverse aortic constriction (TAC) surgery

PROVIDER: PRJNA655620 | ENA |

REPOSITORIES: ENA

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Expression data from mouse heart post transverse aortic constriction (TAC) -surgery 2 weeks

Project description:Expression data from mouse heart post transverse aortic constriction (TAC) -surgery 2 weeks

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Transcription profiling of hearts from FVB male mice subjected to cardiac pressure overload by transverse aortic constriction to study the quantitative relationships between gene expression and left ventricular hypertrophy

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Transcriptomic analysis of mice heart following transverse aortic constriction (TAC) surgery

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Project description:A number of mediators that have been found to be involved in the pathogenesis of cardiac hypertrophy affecting gene transcription, protein synthesis, metabolism,autophagy, oxidative stress and inﬂammation. These mediators including nuclear transcription factor, microRNAs and long noncoding RNAs. However, the gene expression profiles signaling pathways in the pressure overload-induced cardiac hypertrophy remain unknown. All mice were randomly undertaken sham surgery or TAC for 2 weeks. Hearts were harvested 2 weeks following TAC and performed to further analysis.

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Transcription profiling of left ventricular myocardium after sham or TAC surgery in BL/6N and BL/6J mice

Project description:The most commonly used inbred mouse strain, C57BL/6J, lacks a functional nicotinamide nucleotide transhydrogenase (Nnt) and thus, is protected from pressure-overload-induced oxidative stress and heart failure. We screened for differential gene expression in left ventricular myocardium after sham/transverse aortic constriction (TAC) surgery in 10-12 weeks old mice from BL/6N (functional Nnt) and BL/6J (non-functional Nnt, missense of exons 7-11) strains.

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Gene expression profiling of cardiomyocyte-enriched populations isolated from mice subject to transverse aortic constriction (TAC) and treated with BIX-01294 for 1 week

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Project description:Left ventricular tissues were isolated from wildtype and Isg15 knockout mice 8 weeks after sham or transverse aortic constriction and the metabolomic differences were compared.

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