Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain

ABSTRACT: Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain

PROVIDER: PRJNA655925 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain [human]

Project description:Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain [human]

| PRJNA655926 | ENA

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain [mouse]

Project description:Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain [mouse]

| PRJNA655928 | ENA

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain [mouse]

Project description:A measles virus (MeV) isolate bearing a single amino acid change in the fusion protein (F) -- L454W -- was identified in two patients who died of MeV central nervous system (CNS) infection. We analyzed whether this mutation confers an advantage over wild type virus in the CNS, thereby contributing to disease in these patients. Using murine ex vivo organotypic brain cultures and human induced pluripotent stem cell-derived brain organoids, we show that specific CNS adaptive mutations in F result in augmented spread of virus ex vivo and that this is associated with an enhanced innate immune response. The spread of virus in brain organoids is blocked by an inhibitory peptide that targets F, confirming that dissemination in the brain tissue is attributable to F. A single mutation in MeV F thus alters the fusion complex to render the virus more neuropathogenic, allowing it to propagate in the face of the innate immune response.

2020-08-08 | GSE155885 | GEO

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain [human]

2020-08-08 | GSE155884 | GEO

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-08-08 | GSE155886 | GEO

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain.

Project description: Not available

| S-EPMC8263006 | biostudies-literature

Measles morbillivirus

Project description:Measles virus overview

| PRJNA70483 | ENA

Measles morbillivirus

Project description:CNS Measles morbillivirus

| PRJNA594952 | ENA

PVRL Is A Receptor For Measles Virus

Project description:Measles virus infects serum activated airway epithelial cells and many adenocarcinoma cell lines. A microarray analysis was performed on virus permissive versus non-permissive cells. Membrane protein genes that were upregulated in permissive cells were tested as receptor/entry factors. Membrane protein genes that were upregulated in smooth airway epithelial cells (SAEC) following growth in 10% fetal calf serum that made the cell line permissive to measles virus were identified. Membrane protein genes that were upregulated in adenocarcinoma cells that were permissive to wild type measles virus infection were identified.

2011-07-29 | GSE26636 | GEO

Measles morbillivirus

Project description:MeaNS - Measles Nucleotide Surveillance Program

| PRJNA68251 | ENA