Genomics

Dataset Information

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Gene expression analysis of 120 hpf zebrafish livers following 24 hour iAs exposure


ABSTRACT: Gene expression analysis of 120 hpf zebrafish livers following 24 hour iAs exposure

PROVIDER: PRJNA657855 | ENA |

REPOSITORIES: ENA

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Publications

Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish.

Delaney Patrice P   Ramdas Nair Anjana A   Palmer Catherine C   Khan Nouf N   Sadler Kirsten C KC  

Toxicology and applied pharmacology 20201102


Inorganic arsenic (iAs) is one of the most endemic toxicants worldwide and oxidative stress is a key cellular pathway underlying iAs toxicity. Other cellular stress response pathways, such as the unfolded protein response (UPR), are also impacted by iAs exposure, however it is not known how these pathways intersect to cause disease. We optimized the use of zebrafish larvae to identify the relationship between these cellular stress response pathways and arsenic toxicity. We found that the window  ...[more]

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