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HIF1A signaling selectively supports proliferation of breast cancer in the brain [HIF1A KD]

ABSTRACT: HIF1A signaling selectively supports proliferation of breast cancer in the brain [HIF1A KD]

PROVIDER: PRJNA659858 | ENA |

REPOSITORIES: ENA

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HIF1A signaling selectively supports proliferation of breast cancer in the brain [HIF1A KD]

Project description:Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find that cultured circulating tumor cells (CTCs), derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibit striking differences in proliferative potential in the brain. Derivative cell lines generated by serial intracranial injections acquire selectively increased proliferative competency in the brain, with reduced orthotopic tumor growth. Increased Hypoxia Inducible Factor 1A (HIF1A)-associated signaling correlates with enhanced proliferation in the brain, and shRNA-mediated suppression of HIF1A or drug inhibition of HIF-associated glycolytic pathways selectively impairs brain tumor growth while minimally impacting mammary tumor growth. In clinical specimens, brain metastases have elevated HIF1A protein expression, compared with matched primary breast tumors, and, in patients with brain metastases, hypoxic signaling in CTCs predicts decreased overall survival. The selective activation of hypoxic signaling by metastatic cancers in the brain may be an opportunity for therapeutic intervention.

2020-10-17 | GSE156942 | GEO

HIF1A signaling selectively supports proliferation of breast cancer in the brain

Project description:HIF1A signaling selectively supports proliferation of breast cancer in the brain

| PRJNA659643 | ENA

HIF1A signaling selectively supports proliferation of breast cancer in the brain [F1 vs parental]

Project description:HIF1A signaling selectively supports proliferation of breast cancer in the brain [F1 vs parental]

| PRJNA659856 | ENA

HIF1A signaling selectively supports proliferation of breast cancer in the brain [parental CTCs inVitro]

Project description:HIF1A signaling selectively supports proliferation of breast cancer in the brain [parental CTCs inVitro]

| PRJNA659859 | ENA

HIF1A signaling selectively supports proliferation of breast cancer in the brain [parental CTCs inVitro]

2020-10-17 | GSE156943 | GEO

HIF1A signaling selectively supports proliferation of breast cancer in the brain [F1 vs parental]

2020-10-17 | GSE156940 | GEO

HIF1A signaling selectively supports proliferation of breast cancer in the brain [brain vs mammary fat pad]

2020-10-17 | GSE156941 | GEO

HIF1A signaling selectively supports proliferation of breast cancer in the brain [brain vs mammary fat pad]

Project description:HIF1A signaling selectively supports proliferation of breast cancer in the brain [brain vs mammary fat pad]

| PRJNA659857 | ENA

HIF1A signaling selectively supports proliferation of breast cancer in the brain.

Project description: Not available

| S-EPMC7725834 | biostudies-literature

Expression data from HIF1A WT vs KD Madin-Darby canine kidney epithelial cells (MDCK strain II cells (ATCC:CCL-34)) under normoxic and hypoxic conditions

Project description:The expression of TGFbeta pathway genes were downregulated in HIF1A KD Madin-Darby canine kidney epithelial cells (MDCKII) in hypoxic condition. We used microarray to study the differential expression of genes in HIF1A knockdown versus WT Madin-Darby canine kidney epithelial cells (MDCKII)

2017-02-11 | GSE94772 | GEO

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