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Characterization of the epitranscriptomic landscape of HIV-infected cells IV

ABSTRACT: Characterization of the epitranscriptomic landscape of HIV-infected cells IV

PROVIDER: PRJNA660419 | ENA |

REPOSITORIES: ENA

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Characterization of the epitranscriptomic landscape of HIV-infected cells IV

Project description:In this study, we used a productive HIV infection model, consisting of the CD4+ SupT1 T cell line infected with a VSV-G pseudotyped HIVeGFP-based vector, to explore the transcriptomic and m6A/m5C epitranscriptomic lansdcape upon HIV infection, and compare it to mock-treated cells at 12h, 24h, and 36h post infection.

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Characterization of the epitranscriptomic landscape of HIV-infected cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:Several prior reports have demonstrated that the epitranscriptomic addition of m6A to viral transcripts promotes the replication and pathogenicity of a wide range of viruses yet the underlying mechanism(s) causing this positive effect has remained unclear. It is known that m6A function is largely mediated by cellular m6A binding proteins or readers, however, how these m6A reader proteins contribute to the regulation of HIV-1 gene expression has remained controversial. Here, we confirm that m6A indeed enhances HIV-1 gene expression. We demonstrate that this effect is collectively mediated by the cytoplasmic reader YTHDF2, which increases HIV-1 transcript stability, and the nuclear m6A reader YTHDC1, which binds HIV-1 RNA at 7 distinct m6A methylated sites, regulating viral transcript alternative splicing.

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