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Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [single-cell RNA-seq]

ABSTRACT: Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [single-cell RNA-seq]

PROVIDER: PRJNA660812 | ENA |

REPOSITORIES: ENA

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Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche

Project description:Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche

| PRJNA660810 | ENA

Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [bulk RNA]

Project description:Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [bulk RNA]

| PRJNA660813 | ENA

Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [2022_RNA_2]

Project description:In addition to adipocytes, adipose tissue (AT) is populated by mesenchymal stem cells (MSC) in stages of commitment to the adipocyte lineage, and immune cells which support homeostatic tissue function. How MSC and immune cells interact during infection is poorly understood. We found that during intestinal nematode infection, MSC in gut-associated AT (mFAT) exhibit a bias away from commitment to the adipocyte lineage towards a pluripotent progenitor state. During this time, MSC became metabolically active, and began secreting the alarmins IL-33 and TSLP, and extracellular matrix collagens. In parallel, mFAT became irreversibly populated by Th2 resident memory (Th2RM) cells, which make the tissue modulatory cytokines amphiregulin and TGFβ1. Secretion of these cytokines, and Th2RM activation and maintenance, was driven by IL-33 and TSLP and in turn MSC activation was induced by amphiregulin and TGFβ1. Our findings link Th2RM cells to reversible mFAT remodeling during intestinal infection and underscore the reciprocal dependence of stroma and resident immune cells for lasting tissue immunity.

2022-10-13 | GSE215137 | GEO

Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [2022_RNA_1]

2022-10-13 | GSE215136 | GEO

Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [bulk RNA]

2022-08-18 | GSE157312 | GEO

Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche [single-cell RNA-seq]

2022-04-15 | GSE157313 | GEO

Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease

Project description:Chronic inflammation driven by persistent antigenic challenge with dietary gluten permanently reshapes the tissue-resident TCRgd+ intraepithelial lymphocyte compartment in patients with celiac disease.

2018-12-12 | GSE123649 | GEO

Intestinal type 2 inflammation reprograms mesenteric adipose tissue and permanently alters its resident immune cell niche

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-18 | GSE157314 | GEO

Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease

Project description:Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease

| PRJNA509448 | ENA

Mesenteric fibrosis in small intestinal neuroendocrine tumors.

Project description:Assessment of mesenteric fibrosis (MF) presence and severity in small-intestinal neuroendocrine tumors (SI-NETs) remains a diagnostic challenge. To explore possible biomarkers for MF presence, a proteomic analysis was performed of the tumor and stroma compartment of primary SI-NETs and paired mesenteric metastasis.

2022-05-20 | PXD029979 | Pride

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