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PiRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development

ABSTRACT: piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development

PROVIDER: PRJNA660820 | ENA |

REPOSITORIES: ENA

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piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development

Project description:Eukaryotic genomes harbor invading transposable elements silenced by PIWI-interacting RNAs (piRNAs) to maintain genome integrity in animal germ cells. However, whether piRNAs also regulate endogenous gene expression programs remains unclear. Here, we show that C. elegans piRNAs trigger the transcriptional silencing of hundreds of spermatogenic genes during spermatogenesis, promoting sperm differentiation and function. This silencing signal requires the piRNA-dependent small RNA biogenesis and loading into downstream nuclear effectors, which correlates with the dynamic reorganization of two distinct perinuclear biomolecular condensates present in germ cells. In addition, the silencing capacity of piRNAs is temporally counteracted by the Argonaute CSR-1, which targets and licenses spermatogenic gene transcription. The spatial and temporal overlap between these opposing small RNA pathways contributes to setting up the timing of the spermatogenic differentiation program. Thus, our work identifies a prominent role for piRNAs as direct regulators of endogenous transcriptional programs during germline development and gamete differentiation. This SuperSeries is composed of the SubSeries listed below.

2021-11-20 | GSE157319 | GEO

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [GRO-seq]

2021-11-20 | GSE157316 | GEO

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [RNA-seq]

2021-11-20 | GSE157317 | GEO

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [small RNA-IP-seq]

2021-11-20 | GSE157318 | GEO

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [GRO-seq]

Project description:piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [GRO-seq]

| PRJNA660822 | ENA

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [RNA-seq]

Project description:piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [RNA-seq]

| PRJNA660823 | ENA

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [small RNA-IP-seq]

Project description:piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [small RNA-IP-seq]

| PRJNA660824 | ENA

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development.

Project description: Not available

| S-EPMC8796119 | biostudies-literature

Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells

Project description:Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the maternally transmitted piRNAs play a role in the silencing of somatic TEs is, however, unknown. Here we show that maternally transmitted piRNAs from the tirant retrotransposon in Drosophila are required for the somatic silencing of the TE and correlate with an increase in histone H3K9 trimethylation an active tirant copy. Comparison of tirant piRNAs in two Drosophila simulans natural populations.

2013-04-09 | E-GEOD-40592 | biostudies-arrayexpress

Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells

2013-04-09 | GSE40592 | GEO

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