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Derivation of endometrial gland organoids from term placenta

ABSTRACT: Derivation of endometrial gland organoids from term placenta

PROVIDER: PRJNA661086 | ENA |

REPOSITORIES: ENA

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Derivation of endometrial gland organoids from term placenta

Project description:A limitation of current methods for the generation of endometrial gland organoids is their reliance on decidua isolated from endometrial biopsies or elective abortion. Here we report the establishment of endometrial gland organoids from decidua isolated from term placental membranes. These organoids express typical markers of glandular epithelia such as E-cadherin, Laminin and Cytokeratin 7, and can be propagated in cell culture through multiple passages. Additionally, we identified potential survival factors for the co-culture of organoids and endometrial stromal fibroblasts. These modifications facilitate the generation of patient-specific endometrial gland organoids with known pregnancy outcomes.

2020-09-03 | GSE157380 | GEO

Human endometrial organoids

Project description:Human endometrial organoids

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Human endometrial organoids

Project description:Human endometrial organoid cultures were established from the decidual samples. We analyzed the global expression profiles of the endometrial organoids. Next, we determined the global expression patterns upon estrogen treatment and compared them to untreated controls.

2021-01-27 | GSE128605 | GEO

Transcriptomic profiling of patient-derived endometrial cancer organoids (Berg HF)

Project description:Patient-derived endometrial cancer organoids. The data was used to compare gene expression profile between organoids, and to explore whether an organoid-derived gene signature could predict disease outcomes in independent patient cohorts.

2021-07-16 | E-MTAB-10664 | biostudies-arrayexpress

Progesterone signaling in endometrial epithelial organoids

Project description:3D chromatin structure of endometrial organoids and PRKO and Sox17cKO mouse uterus

2022-05-26 | GSE200803 | GEO

Progesterone signaling in endometrial epithelial organoids

Project description:Progesterone signaling in endometrial epithelial organoids

| PRJNA826845 | ENA

Hormone responsiveness and spatial heterogeneityof apical-out endometrial organoids

Project description:We have developed apical-out (AO)- endometrial organoids (EMO) that emulate the in vivo archtecture of endometrial epithelium. The AO-EMO exposes the apical surface of the epithelium. To explore the hormone responsiveness and spatial heterogeneity of AO-EMO, we conducted transcriptomic analysis.

2023-11-11 | GSE239657 | GEO

Term placenta transcriptomes

Project description:Term placenta transcriptomes

| PRJNA345631 | ENA

Gene expression profile in endometrial organoids cultured in normal follicular phase vs PCOS-like hormone profile

Project description:We generated scaffold-free endometrial organoids from human primary endometrial tissues. These organoids were subjected to stepwise hormone treatments for 14 days mimicking the proliferative phase of menstrual cycle or with constantly high testosterone mimicking PCOS conditions

2019-12-01 | GSE128328 | GEO

RNA-seq of Pluripotent Stem Cell-Derived Endometrial Stromal Fibroblasts in Monolayer Differentiation and in Co-culture with Endometrial Epithelial Organoids

Project description:H9 Pluripotent Stem Cells (PSC) were differentiated to Endometrial Stromal Fibroblasts (PSC-ESF) in monolayer over the course of 12 days. Gene expression was measured at day 0, day 4, day 8, and day 12 of differentiation. At day 12, PSC-ESF were dissociated from monolayer culture for co-culture with endometrial epithelial organoids established from term decidua. Gene expression was also measured after 26 days in co-culture (Cycle 1, vehicle or cAMP/progesterone/estradiol) and after 52 days in co-culture (Cycle 2, vehicle or cAMP/progesterone/estradiol)

2021-05-05 | E-MTAB-10375 | biostudies-arrayexpress

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