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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

ABSTRACT: Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

PROVIDER: PRJNA661756 | ENA |

REPOSITORIES: ENA

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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

Project description:Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities. Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.

2020-11-18 | GSE157547 | GEO

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

2020-11-18 | GSE153352 | GEO

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

Project description:Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

| PRJNA644900 | ENA

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

Project description:Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

| PRJNA661755 | ENA

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-18 | GSE157548 | GEO

Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.

Project description: Not available

| S-EPMC7876147 | biostudies-literature

Engaging Black Men in Colorectal Cancer Screening

Project description:To determine the unmet needs, attitudes, barriers and facilitators of African American (AA)/ Black men use of colorectal cancer screening and describe how community leaders such as barbers may act as Community Champions to educate and facilitate screening participation.

| 70579 | ecrin-mdr-crc

Genomic profile of fatigued men receiving localized radiation therapy

Project description:Microarray gene expression of peripheral blood of the prostate cancer patients receiving localized external beam radiation therapy (EBRT) Assay processed at EBRT time points, baseline, midpoint (days 19-21) and endpoint (days 38-42)

2015-06-17 | GSE69961 | GEO

Cooperation Between PRMT1 and PRMT6 Drives Lung Cancer Health Disparities Among Black/African American Men

Project description:SUMMARY Non-Hispanic Black/African American (Black/AA) men in the United States have disproportionally higher incidence and mortality rates of lung cancer compared to non-Hispanic White (NHW) men. Biological factors are believed to play critical roles in driving the disparities. Nevertheless, large-scale genomic studies fail to identify significant somatic differences in lung cancer driver genes contributing to the disparities. Elevated expression of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis is observed in many cancer types. Here, we observed a higher PRMT6 expression in lung cancer of Black/AA men compared to NHW men. PRMT6 formed a heteromer complex with PRMT1 to catalyze arginine methylation of interleukin enhancer-binding factor 2 essential for cell proliferation. Disrupting PRMT1/PRMT6 heteromer complex by a competitive peptide reduced cell proliferation in non-small cell lung cancer cell lines and lung cancer patient-derived organoids. This work implicates that PRMT1/PRMT6 heteromer complex contributes to poorer lung cancer outcomes in Black/AA men vs. NHW men that could serve as a target to eliminate cancer health disparities.

2023-12-15 | MSV000093674 | MassIVE

Validation Study of Linear Quantification of CD3+ Cells in Localized Colorectal Carcinomas

Project description:The purpose of this study is to confirm that linear quantification of CD3+ cells is a prognostic biomarker in localized colorectal carcinomas.

| 2183880 | ecrin-mdr-crc

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