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RNA-seq analysis of αPD-1 treatment outcomes in IL-34 expressing or not expressing CT26 cell line

ABSTRACT: RNA-seq analysis of αPD-1 treatment outcomes in IL-34 expressing or not expressing CT26 cell line

PROVIDER: PRJNA662114 | ENA |

REPOSITORIES: ENA

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RNA-seq analysis of αPD-1 treatment outcomes in IL-34 expressing or not expressing CT26 cell line

Project description:Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage. In this study, we show that cancer cells-derived IL-34 mediates resistance to immune checkpoint blockade regardless of CSF-1 existence. In a therapeutic study of a programmed death-1 and cytotoxic T-lymphocyte-associated antigen-4 blocking monoclonal antibody, the expression of IL-34 in tumors was accompanied with limited benefits compared to IL-34 non-expressing tumors in various murine cancer models. Consistent with its immunosuppressive characteristics, the expression of IL-34 in tumors correlates with decreased frequencies of cellular (such as CD8+ and CD4+ T cells) and molecular (including various cytokines and chemokines) effectors at the tumor microenvironment. In addition, IL-34 blockade expands the M1-macrophage population. Then, a neutralizing antibody against IL-34 helped to reverse these effects and improved the therapeutic effects of the immune checkpoint blockade in combinatorial therapeutic models, including a patient-derived xenograft model of primary lung adenocarcinoma. Collectively, we revealed that tumor-derived IL-34 inhibits the efficacy of immune checkpoint blockade and proposed the utility of IL-34 blockade as a new strategy for cancer therapy.

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RNA-seq of CT26 subcutaneous tumors expressing control or Gna13 targeting sgRNAs

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RNA-seq of CT26 cells expressing TRE-GNA13 Q226L

Project description:RNA-seq of CT26 cells expressing TRE-GNA13 Q226L

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IL-34-differenciated CD14+CD115+ monocytes expand and potentiate IL-34+ Tregs to control human transplant rejection

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TCR variable regions transcripts of CT26-shppp2r1a and CT26-scr samples

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CSF-1 and IL-34 drive distinct microglial programs in the brain tissue

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IL-34 actions on FOXP3+ Tregs and CD14+ monocytes control human graft rejection

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2020-05-27 | GSE151194 | GEO

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