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Integrative transcriptomic and proteomic analyses reveal that 15,16-dihydrotanshinone I inhibits infantile hemangioma by interfering in posttranscriptional processing of hypoxia-inducible factor 1

ABSTRACT: Integrative transcriptomic and proteomic analyses reveal that 15,16-dihydrotanshinone I inhibits infantile hemangioma by interfering in posttranscriptional processing of hypoxia-inducible factor 1

PROVIDER: PRJNA663313 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12637089_1.fastq.gz	Fastqsanger.gz
	SRR12637089_2.fastq.gz	Fastqsanger.gz
	SRR12637090_1.fastq.gz	Fastqsanger.gz
	SRR12637090_2.fastq.gz	Fastqsanger.gz
	SRR12637091_1.fastq.gz	Fastqsanger.gz

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Integrative transcriptomic and proteomic analyses reveal that 15,16-dihydrotanshinone I inhibits infantile hemangioma by interfering in posttranscriptional processing of hypoxia-inducible factor 1

Project description:Our team found that 15,16-dihydrotanshinone I (DHTS) was significantly effective at inhibiting infantile hemangioma proliferation in vitro and in vivo. To investigate the underlying mechanism by which DHTS inhibits hemangioma, we compared the transcriptomes of control and DHTS-treated hemangioma cells.

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Integrative transcriptomic and proteomic analyses reveal that 15,16-dihydrotanshinone I inhibits infantile hemangioma by interfering in posttranscriptional processing of hypoxia-inducible factor 1

Project description:Integrative transcriptomic and proteomic analyses reveal that 15,16-dihydrotanshinone I inhibits infantile hemangioma by interfering in posttranscriptional processing of hypoxia-inducible factor 1

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Project description:Surgical specimens from children with infantile hemangioma or lymphatic malformations, as well as healthy appearing adjacent skin, were analyzed by microarray analysis of microRNA expression. Unsupervised hierarchical clustering was performed to identify microRNAs that were differentially expressed in IH compared to lymphatic malformations and skin 19 patients who underwent surgical excision of either a lymphatic malformation or infantile hemangioma were used in the study. 5 patients have multiple samples on the array and these duplicates are from different regions of the excised tissue or separate lesions as indicated. Tissue was snap frozen in liquid nitrogen and used for RNA extraction

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Project description:Whole transcriptome comparisons of proliferating pure cultures of neonatal dermal microvacsular endothelial cells to infantile hemangioma endothelial cells. The total RNA was obtained from human dermal microvascular endothelial cells and infantile hemangioma endothelial cells. Illumina microarrays were performed to determine the whole genome expression differences between the cell lines.

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Project description:Infantile hemangioma (IH) was one of the most common vascular tumors during childhood. Long non coding RNAs (lncRNAs) play great roles in angiogenesis; the involvement of lncRNAs in hemangioma remains unknown. We aim to investigate the differential expression of lncRNA between hemangioma and the adjacent normal tissues, with a view to studying the biological function of lncRNAs and their involvement in the pathogenesis of hemangioma. The differential lncRNAs expression profiles of hemangioma were established by lncRNA microarray. Bioinformatic analyses were applied for further study of these differentially expressed lncRNAs. A total of 2116 differentially expressed lncRNAs were identified, among these lncRNAs, 1259 were up-regulated and 857 were down-regulated more than two-fold.

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