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Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in endothelial cells after 18 weeks of high fat diet

ABSTRACT: Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in endothelial cells after 18 weeks of high fat diet

PROVIDER: PRJNA664331 | ENA |

REPOSITORIES: ENA

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Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in endothelial cells after 18 weeks of high fat diet

Project description:Vascular EGF receptors (EGFR) are supposed to be relevant for function and structure of arterial vessels. Recently, we showed in genetic mouse models that vascular smooth muscle (VSMC) EGFR is required for proper physiological function and structure as well as for pathophysiological alterations induced by angiotensin II or obesity. The importance of endothelial (EC) EGFR in vivo is unknown. Therefore we analyzed the impact of EC-EGFR knockout on vascular and renal function under control condition as well as in obesity in comparison to VSMC-KO.

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Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in vascular smooth muscle cells after 18 weeks of high fat diet

Project description:Obesity causes diabetes type 2 (DMT2) leading to vascular dysfunction and finally renal end-organ damage. Vascular smooth muscle (VSM) EGF receptor (EGFR) modulates vascular wall homeostasis in part via serum response factor (SRF), a major regulator of VSM differentiation and a sensor for glucose. We investigated the role of VSM-EGFR during obesity-induced renovascular dysfunction and the EGFR-hyperglycemia crosstalk.

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Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in vascular smooth muscle cells after 18 weeks of high fat diet

Project description:Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in vascular smooth muscle cells after 18 weeks of high fat diet

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Aortas of mice on high fat diet

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Gene expression changes in aortas of mice on high fat versus regular chow diet.

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