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Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade

ABSTRACT: Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade

PROVIDER: PRJNA664789 | ENA |

REPOSITORIES: ENA

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Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade I

Project description:Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade I

| PRJNA664788 | ENA

Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade III

Project description:Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade III

| PRJNA664793 | ENA

Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade II

Project description:Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade II

| PRJNA664794 | ENA

Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade III

Project description:After ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in post-stroke blood cells. This molecular switch may re-balance acetylcholine signaling in CD14+ monocytes by regulating their gene expression and modulating post-stroke immunity. Our observations point to tRFs as new molecular regulators of post-stroke immune responses that may become potential therapeutic targets.

2020-12-31 | GSE158313 | GEO