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Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart

ABSTRACT: Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart

PROVIDER: PRJNA666393 | ENA |

REPOSITORIES: ENA

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Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress

Project description:The paralogous genes Nppa and Nppb are organized in an evolutionary conserved cluster and are a valuable model to study coregulation and regulatory landscape organization during heart development and disease. Here, we analyzed the chromatin conformation, epigenetic status and enhancer potential of sequences of the Nppa-Nppb cluster in vivo. Our data indicate that the regulatory landscape of the cluster is present within a 60 kbp domain centered around Nppb. Both promoters and several potential regulatory elements interact with each other in a similar manner in different tissues and developmental stages. The distribution of H3K27ac and the association of Pol2 across the locus changed during cardiac hypertrophy, revealing their potential involvement in stress-mediated gene regulation. In summary, the developmental regulation and stress-response of the Nppa-Nppb cluster involve the concerted action of multiple enhancers and epigenetic changes distributed across a structurally rigid regulatory domain. We have used 4C-seq on several viewpoints around the Nppa-Nppb gene cluster in the heart and liver samples to investigate the role of chromatin conformation on regulation of Nppa and Nppb expression during heart development and disease.

2016-07-02 | E-GEOD-81057 | biostudies-arrayexpress

Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (CUT&RUN)

Project description:CUT&RUN H3K27ac PCM-1 sorted left ventricle of Nppa-Nppb double-knockout

2020-11-25 | GSE146734 | GEO

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress

2016-07-02 | GSE81057 | GEO

Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart of RE3 mutants

Project description:Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart of RE3 mutants

| PRJNA648832 | ENA

Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart after cardiac stress

Project description:Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart after cardiac stress

| PRJNA666327 | ENA

Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (CUT&RUN)

Project description:Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (CUT&RUN)

| PRJNA611779 | ENA

Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (RNA-Seq)

Project description:Genetic dissection of a super enhancer controlling the Nppa-Nppb locus in the heart (RNA-Seq)

| PRJNA611780 | ENA

Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-30 | GSE158735 | GEO

Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart of RE3 mutants

Project description:High-resolution chromosome conformation capture-sequencing of RE3 homozygous mutants

2021-07-30 | GSE155140 | GEO

Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart after cardiac stress

Project description:High-resolution chromosome conformation capture-sequencing of wildtype mice left ventricle after cardiac stress (i.e. hypertrophy and myocardial infarction)

2021-07-30 | GSE158708 | GEO

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